Search Results
Overview
| Uniprot ID | Q62936 |
|---|---|
| Protein Name | Disks large homolog 3 |
| Gene Name | Dlg3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 494 | EYSRFESKIHDLREQ |
| 74 | PTPRTKAKLIPTGRD |
Function
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling
Protein Sequence
10
MHKHQHCCKC
20
PECYEVTRLA
30
ALRRLEPPGY
40
GDWQVPDPYG
50
PSGGNGASSG
60
YGGYSSQTLP
70
SQAGATPTPR
80
TKAKLIPTGR
90
DVGPVPPKPV
100
PGKNTPKLNG
110
SGPSWWPECT
120
CTNRDWYEQA
130
SPAPLLVNPE
140
ALEPSLSVNG
150
SDGMFKYEEI
160
VLERGNSGLG
170
FSIAGGIDNP
180
HVPDDPGIFI
190
TKIIPGGAAA
200
MDGRLGVNDC
210
VLRVNEVDVS
220
EVVHSRAVEA
230
LKEAGPVVRL
240
VVRRRQPPPE
250
TIMEVNLLKG
260
PKGLGFSIAG
270
GIGNQHIPGD
280
NSIYITKIIE
290
GGAAQKDGRL
300
QIGDRLLAVN
310
NTNLQDVRHE
320
EAVASLKNTS
330
DMVYLKVAKP
340
GSLHLNDMYA
350
PPDYASTFTA
360
LADNHISHNS
370
SLGYLGAVES
380
KVTYPAPPQV
390
PPTRYSPIPR
400
HMLAEEDFTR
410
EPRKIILHKG
420
STGLGFNIVG
430
GEDGEGIFVS
440
FILAGGPADL
450
SGELRRGDRI
460
LSVNGVNLRN
470
ATHEQAAAAL
480
KRAGQSVTIV
490
AQYRPEEYSR
500
FESKIHDLRE
510
QMMNSSMSSG
520
SGSLRTSEKR
530
SLYVRALFDY
540
DRTRDSCLPS
550
QGLSFSYGDI
560
LHVINASDDE
570
WWQARLVTPH
580
GESEQIGVIP
590
SKKRVEKKER
600
ARLKTVKFHA
610
RTGMIESNRD
620
FPGLSDDYYG
630
AKNLKGVTSN
640
TSDSESSSKG
650
QEDAILSYEP
660
VTRQEIHYAR
670
PVIILGPMKD
680
RVNDDLISEF
690
PHKFGSCVPH
700
TTRPRRDNEV
710
DGQDYHFVVS
720
REQMEKDIQD
730
NKFIEAGQFN
740
DNLYGTSIQS
750
VRAVAERGKH
760
CILDVSGNAI
770
KRLQQAQLYP
780
IAIFIKPKSI
790
EALMEMNRRQ
800
TYEQANKIFD
810
KAMKLEQEFG
820
EYFTAIVQGD
830
SLEEIYNKIK
840
QIIEDQSGHY
IWVPSPEKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032281 | AMPA glutamate receptor complex |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0001736 | establishment of planar polarity |
| Biological Process | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0043113 | receptor clustering |
| Biological Process | GO:0097120 | receptor localization to synapse |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.