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Overview

Uniprot IDQ62950
Protein NameDihydropyrimidinase-related protein 1
Gene NameCrmp1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
254 NCPVYITKVMSKSAA
368 RMTVVWDKAVATGKM
423 KMKTLTAKSHKSTVE
463 DGNISVSKGMGRFIP
472 MGRFIPRKPFPEHLY
487 QRVRIRSKVFGLHSV
520 AAPAPSAKSSPSKHQ
525 SAKSSPSKHQPPPIR
7 *MSHQGKKSIPHITS

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in axon guidance (By similarity). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (By similarity). Involved in invasive growth and cell migration. May participate in cytokinesis (By similarity)

Protein Sequence

10 MSHQGKKSIP 20 HITSDRLLIR 30 GGRIINDDQS 40 FYADVYLEDG 50 LIKQIGENLI 60 VPGGVKTIEA 70 NGRMVIPGGI 80 DVNTYLQKPS 90 QGMTSADDFF 100 QGTRAALAGG 110 TTMIIDHVVP 120 EPGSSLLTSF 130 EKWHEAADTK 140 SCCDYSLHVD 150 ITSWYDGVRE 160 ELEVLVQDKG 170 VNSFQVYMAY 180 KDLYQMSDSQ 190 LYEAFTFLKG 200 LGAVILVHAE 210 NGDLIAQEQK 220 RILEMGITGP 230 EGHALSRPEE 240 LEAEAVFRAI 250 AIAGRINCPV 260 YITKVMSKSA 270 ADIIALARKK 280 GPLVFGEPIA 290 ASLGTDGTHY 300 WSKNWAKAAA 310 FVTSPPLSPD 320 PTTPDYLTSL 330 LACGDLQVTG 340 SGHCPYSTAQ 350 KAVGKDNFTL 360 IPEGVNGIEE 370 RMTVVWDKAV 380 ATGKMDENQF 390 VAVTSTNAAK 400 IFNLYPRKGR 410 IAVGSDADVV 420 IWDPDKMKTL 430 TAKSHKSTVE 440 YNIFEGMECH 450 GSPLVVISQG 460 KIVFEDGNIS 470 VSKGMGRFIP 480 RKPFPEHLYQ 490 RVRIRSKVFG 500 LHSVSRGMYD 510 GPVYEVPATP 520 KHAAPAPSAK 530 SSPSKHQPPP 540 IRNLHQSNFS 550 LSGAQIDDNN 560 PRRTGHRIVA 570 PPGGRSNITS LG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005819 spindle
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0030426 growth cone
Cellular Component GO:0030496 midbody
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0098793 presynapse
Molecular Function GO:0031005 filamin binding
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051219 phosphoprotein binding
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0048666 neuron development
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0071526 semaphorin-plexin signaling pathway

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.