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Overview

Uniprot IDQ62951
Protein NameDihydropyrimidinase-related protein 4
Gene NameDpysl4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
250 YITKVMSKGAADMVA
260 ADMVAQAKRRGVVVF
517 ARASCPGKISVPPVR
549 IARRTAQKIMAPPGG

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Protein Sequence

10 IPRITSDRLL 20 IKGGKIVNDD 30 QSFHADLYVE 40 DGLIKQIGEN 50 LIVPGGIKTI 60 DAHGLMVLPG 70 GVDVHTRLQM 80 PVLGMTPADD 90 FCQGTKAALA 100 GGTTMILDHV 110 FPDAGVSLLA 120 AYEQWRERAD 130 SAACCDYSLH 140 VDIPRWHEST 150 KEELEALVRD 160 KGVNSFLVFM 170 AYKDRCQCTD 180 GQIYEIFSLI 190 RDLGAVAQVH 200 AENGDIVEEE 210 QKRLLEQGIT 220 GPEGHVLSHP 230 EEVEAEAVYR 240 AVTIAKQANC 250 PLYITKVMSK 260 GAADMVAQAK 270 RRGVVVFGEP 280 ITASLGTDGS 290 HYWSKNWAKA 300 AAFVTSPPIN 310 PDPTTADHLT 320 SLLSSGDLQV 330 TGSAHCTFTT 340 AQKAVGKDNF 350 TLIPEGINGI 360 EERMSVVWEK 370 CVASGKMDEN 380 EFVAVTSTNA 390 AKIFNFYPRK 400 GRVAVGSDAD 410 LVIWNPRATK 420 VISAKSHNLN 430 VEYNIFEGVE 440 CRGMPTVVIS 450 QGRVVLEDGN 460 LLVTPGAGRF 470 IPRKTFPDFV 480 YKRIKARNRL 490 AEIHGVPRGL 500 YDGPVHEVML 510 PAKPGSGTQA 520 RASCPGKISV 530 PPVRNLHQSG 540 FSLSGSQADD 550 HIARRTAQKI 560 MAPPGGRSNI TSLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0031005 filamin binding
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Molecular Function GO:0051219 phosphoprotein binding
Biological Process GO:0048666 neuron development

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.