Search Results
Overview
| Uniprot ID | Q63918 |
|---|---|
| Protein Name | Caveolae-associated protein 2 |
| Gene Name | Cavin2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | NDLTKLSKYQASTSN |
| 261 | KMNKLGTKIVSVERR |
Function
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (PubMed:23652019). May play a role in targeting PRKCA to caveolae (By similarity)
Protein Sequence
10
MGEDAAQAEK
20
FQHPNTDMLQ
30
EKPSSPSPMP
40
SSTPSPSLNL
50
GSTEEAIRDN
60
SQVNAVTVHT
70
LLDKLVNMLD
80
AVRENQHNME
90
QRQINLEGSV
100
KGIQNDLTKL
110
SKYQASTSNT
120
VSKLLEKSRK
130
VSAHTRAVRE
140
RLERQCVQVK
150
RLENNHAQLL
160
RRNHFKVLIF
170
QEESEIPASV
180
FVKEPVPSAA
190
EGKEELADEN
200
KSLEETLHNV
210
DLSSDDELPR
220
DEEALEDSAE
230
EKMEESRAEK
240
IKRSSLKKVD
250
SLKKAFSRQN
260
IEKKMNKLGT
270
KIVSVERREK
280
IKKSLTPNHQ
290
KASSGKSSPF
300
KVSPLSFGRK
310
KVREGESSVE
320
NETKLEDQMQ
330
EDREEGSFTE
340
GLSEASLPSG
350
LMEGSAEDAE
360
KSARRGNNSA
370
VGSNADLTIE
380
EDEEEEPVAL
390
QQAQQVRYES
400
GYMLNSEEME
410
EPSEKQVQPA
VLHVDQTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Biological Process | GO:0097320 | plasma membrane tubulation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.