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Overview

Uniprot IDQ63HK5
Protein NameTeashirt homolog 3
Gene NameTSHZ3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
890 EESTPAQKRKGRQSN

Function

Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity)

Protein Sequence

10 MPRRKQQAPR 20 RAAAYVSEEL 30 KAAALVDEGL 40 DPEEHTADGE 50 PSAKYMCPEK 60 ELARACPSYQ 70 NSPAAEFSCH 80 EMDSESHISE 90 TSDRMADFES 100 GSIKNEEETK 110 EVTVPLEDTT 120 VSDSLEQMKA 130 VYNNFLSNSY 140 WSNLNLNLHQ 150 PSSEKNNGSS 160 SSSSSSSSSC 170 GSGSFDWHQS 180 AMAKTLQQVS 190 QSRMLPEPSL 200 FSTVQLYRQS 210 SKLYGSIFTG 220 ASKFRCKDCS 230 AAYDTLVELT 240 VHMNETGHYR 250 DDNHETDNNN 260 PKRWSKPRKR 270 SLLEMEGKED 280 AQKVLKCMYC 290 GHSFESLQDL 300 SVHMIKTKHY 310 QKVPLKEPVT 320 PVAAKIIPAT 330 RKKASLELEL 340 PSSPDSTGGT 350 PKATISDTND 360 ALQKNSNPYI 370 TPNNRYGHQN 380 GASYAWHFEA 390 RKSQILKCME 400 CGSSHDTLQE 410 LTAHMMVTGH 420 FIKVTNSAMK 430 KGKPIVETPV 440 TPTITTLLDE 450 KVQSVPLAAT 460 TFTSPSNTPA 470 SISPKLNVEV 480 KKEVDKEKAV 490 TDEKPKQKDK 500 PGEEEEKCDI 510 SSKYHYLTEN 520 DLEESPKGGL 530 DILKSLENTV 540 TSAINKAQNG 550 TPSWGGYPSI 560 HAAYQLPNMM 570 KLSLGSSGKS 580 TPLKPMFGNS 590 EIVSPTKNQT 600 LVSPPSSQTS 610 PMPKTNFHAM 620 EELVKKVTEK 630 VAKVEEKMKE 640 PDGKLSPPKR 650 ATPSPCSSEV 660 GEPIKMEASS 670 DGGFRSQENS 680 PSPPRDGCKD 690 GSPLAEPVEN 700 GKELVKPLAS 710 SLSGSTAIIT 720 DHPPEQPFVN 730 PLSALQSVMN 740 IHLGKAAKPS 750 LPALDPMSML 760 FKMSNSLAEK 770 AAVATPPPLQ 780 SKKADHLDRY 790 FYHVNNDQPI 800 DLTKGKSDKG 810 CSLGSVLLSP 820 TSTAPATSSS 830 TVTTAKTSAV 840 VSFMSNSPLR 850 ENALSDISDM 860 LKNLTESHTS 870 KSSTPSSISE 880 KSDIDGATLE 890 EAEESTPAQK 900 RKGRQSNWNP 910 QHLLILQAQF 920 AASLRQTSEG 930 KYIMSDLSPQ 940 ERMHISRFTG 950 LSMTTISHWL 960 ANVKYQLRRT 970 GGTKFLKNLD 980 TGHPVFFCND 990 CASQIRTPST 1000 YISHLESHLG 1010 FRLRDLSKLS 1020 TEQINSQIAQ 1030 TKSPSEKMVT 1040 SSPEEDLGTS 1050 YQCKLCNRTF 1060 ASKHAVKLHL 1070 SKTHGKSPED 1080 HLLYVSELEK Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0030426 growth cone
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0002087 regulation of respiratory gaseous exchange by nervous system process
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

PMID: N/A