Search Results
Overview
| Uniprot ID | Q64105 |
|---|---|
| Protein Name | Sepiapterin reductase |
| Gene Name | Spr |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 215 | QLARETSKDPELRSK |
| 227 | RSKLQKLKSDGALVD |
Function
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin
Protein Sequence
10
MEADGLGCAV
20
CVLTGASRGF
30
GRALAPQLAR
40
LLSPGSVMLV
50
SARSESMLRQ
60
LKEELGAQQP
70
DLKVVLAAAD
80
LGTEAGVQRL
90
LSAVRELPRP
100
EGLQRLLLIN
110
NAATLGDVSK
120
GFLNVNDLAE
130
VNNYWALNLT
140
SMLCLTSGTL
150
NAFQDSPGLS
160
KTVVNISSLC
170
ALQPYKGWGL
180
YCAGKAARDM
190
LYQVLAAEEP
200
SVRVLSYAPG
210
PLDNDMQQLA
220
RETSKDPELR
230
SKLQKLKSDG
240
ALVDCGTSAQ
250
KLLGLLQKDT
260
FQSGAHVDFY
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004757 | sepiapterin reductase (NADP+) activity |
| Biological Process | GO:0048667 | cell morphogenesis involved in neuron differentiation |
| Biological Process | GO:0042417 | dopamine metabolic process |
| Biological Process | GO:0006558 | L-phenylalanine metabolic process |
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
| Biological Process | GO:0042415 | norepinephrine metabolic process |
| Biological Process | GO:0019889 | pteridine metabolic process |
| Biological Process | GO:0040014 | regulation of multicellular organism growth |
| Biological Process | GO:0042428 | serotonin metabolic process |
| Biological Process | GO:0006729 | tetrahydrobiopterin biosynthetic process |
| Biological Process | GO:0046146 | tetrahydrobiopterin metabolic process |
| Biological Process | GO:0050882 | voluntary musculoskeletal movement |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.