Search Results
Overview
| Uniprot ID | Q64478 |
|---|---|
| Protein Name | Histone H2B type 1-H |
| Gene Name | H2bc9 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | LLPGELAKHAVSEGT |
| 117 | HAVSEGTKAVTKYTS |
| 6 | **MPEPAKSAPAPKK |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MPEPAKSAPA
20
PKKGSKKALT
30
KAQKKDGKKR
40
KRSRKESYSV
50
YVYKVLKQVH
60
PDTGISSKAM
70
GIMNSFVNDI
80
FERIAGEASR
90
LAHYNKRSTI
100
TSREIQTAVR
110
LLLPGELAKH
120
AVSEGTKAVT
KYTSSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0019731 | antibacterial humoral response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0002227 | innate immune response in mucosa |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.