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Overview

Uniprot IDQ64518
Protein NameSarcoplasmic/endoplasmic reticulum calcium ATPase 3
Gene NameAtp2a3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
481 VIKQLMRKEFTLEFS

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen (PubMed:27923914). Contributes to calcium sequestration involved in muscular excitation/contraction

Protein Sequence

10 MEEAHLLSAA 20 DVLRRFSVTA 30 EGGLSLEQVT 40 DARERYGPNE 50 LPTEEGKSLW 60 ELVVEQFEDL 70 LVRILLLAAL 80 VSFVLAWFEE 90 GEETTTAFVE 100 PLVIMLILVA 110 NAIVGVWQER 120 NAESAIEALK 130 EYEPEMGKVI 140 RSDRKGVQRI 150 RARDIVPGDI 160 VEVAVGDKVP 170 ADLRLIEIKS 180 TTLRVDQSIL 190 TGESVSVTKH 200 TDAIPDPRAV 210 NQDKKNMLFS 220 GTNIASGKAL 230 GVAVATGLQT 240 ELGKIRSQMA 250 AVEPERTPLQ 260 RKLDEFGRQL 270 SHAISVICVA 280 VWVINIGHFA 290 DPAHGGSWLR 300 GAVYYFKIAV 310 ALAVAAIPEG 320 LPAVITTCLA 330 LGTRRMARKN 340 AIVRSLPSVE 350 TLGCTSVICS 360 DKTGTLTTNQ 370 MSVCRMFVVA 380 EAEAGTCRLH 390 EFTISGTTYT 400 PEGEVRQGEQ 410 PVRCGQFDGL 420 VELATICALC 430 NDSALDYNEA 440 KGVYEKVGEA 450 TETALTCLVE 460 KMNVFDTDLK 470 GLSRVERAGA 480 CNSVIKQLMR 490 KEFTLEFSRD 500 RKSMSVYCTP 510 TRADPKVQGS 520 KMFVKGAPES 530 VIERCSSVRV 540 GSRTAPLSTT 550 SREHILAKIR 560 DWGSGSDTLR 570 CLALATRDTP 580 PRKEDMHLDD 590 CSRFVQYETD 600 LTFVGCVGML 610 DPPRPEVAAC 620 ITRCSRAGIR 630 VVMITGDNKG 640 TAVAICRRLG 650 IFGDTEDVLG 660 KAYTGREFDD 670 LSPEQQRQAC 680 RTARCFARVE 690 PAHKSRIVEN 700 LQSFNEITAM 710 TGDGVNDAPA 720 LKKAEIGIAM 730 GSGTAVAKSA 740 AEMVLSDDNF 750 ASIVAAVEEG 760 RAIYNNMKQF 770 IRYLISSNVG 780 EVVCIFLTAI 790 LGLPEALIPV 800 QLLWVNLVTD 810 GLPATALGFN 820 PPDLDIMEKP 830 PRNPREALIS 840 GWLFFRYLAI 850 GVYVGLATVA 860 AATWWFLYDT 870 EGPQVTFYQL 880 RNFLKCSEDN 890 PLFAGIDCKV 900 FESRFPTTMA 910 LSVLVTIEMC 920 NALNSVSENQ 930 SLLRMPPWLN 940 PWLLGAVVMS 950 MALHFLILLV 960 PPLPLIFQVT 970 PLSGRQWGVV 980 LQMSLPVILL 990 DEALKYLSRN HMDEKKDLK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0016020 membrane
Cellular Component GO:0031090 organelle membrane
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005246 calcium channel regulator activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0015085 calcium ion transmembrane transporter activity
Molecular Function GO:0030899 calcium-dependent ATPase activity
Molecular Function GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
Molecular Function GO:0005388 P-type calcium transporter activity
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
Biological Process GO:0032469 endoplasmic reticulum calcium ion homeostasis
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.