Search Results
Overview
| Uniprot ID | Q64727 |
|---|---|
| Protein Name | Vinculin |
| Gene Name | Vcl |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 219 | FVTTKNSKNQGIEEA |
| 316 | VGELCAGKERREILG |
| 59 | SNLVRVGKETVQTTE |
| 784 | PKFREAVKAASDELS |
Function
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity)
Protein Sequence
10
MPVFHTRTIE
20
SILEPVAQQI
30
SHLVIMHEEG
40
EVDGKAIPDL
50
TAPVAAVQAA
60
VSNLVRVGKE
70
TVQTTEDQIL
80
KRDMPPAFIK
90
VENACTKLVQ
100
AAQMLQSDPY
110
SVPARDYLID
120
GSRGILSGTS
130
DLLLTFDEAE
140
VRKIIRVCKG
150
ILEYLTVAEV
160
VETMEDLVTY
170
TKNLGPGMTK
180
MAKMIDERQQ
190
ELTHQEHRVM
200
LVNSMNTVKE
210
LLPVLISAMK
220
IFVTTKNSKN
230
QGIEEALKNR
240
NFTVEKMSAE
250
INEIIRVLQL
260
TSWDEDAWAS
270
KDTEAMKRAL
280
ASIDSKLNQA
290
KGWLRDPNAS
300
PGDAGEQAIR
310
QILDEAGKVG
320
ELCAGKERRE
330
ILGTCKMLGQ
340
MTDQVADLRA
350
RGQGASPVAM
360
QKAQQVSQGL
370
DVLTAKVENA
380
ARKLEAMTNS
390
KQSIAKKIDA
400
AQNWLADPNG
410
GPEGEEQIRG
420
ALAEARKIAE
430
LCDDPKERDD
440
ILRSLGEIAA
450
LTSKLGDLRR
460
QGKGDSPEAR
470
ALAKQVATAL
480
QNLQTKTNRA
490
VANSRPAKAA
500
VHLEGKIEQA
510
QRWIDNPTVD
520
DRGVGQAAIR
530
GLVAEGHRLA
540
NVMMGPYRQD
550
LLAKCDRVDQ
560
LTAQLADLAA
570
RGEGESPQAR
580
ALASQLQDSL
590
KDLKAQMQEA
600
MTQEVSDVFS
610
DTTTPIKLLA
620
VAATAPPDAP
630
NREEVFDERA
640
ANFENHSGRL
650
GATAEKAAAV
660
GTANKSTVEG
670
IQASVKTARE
680
LTPQVISAAR
690
ILLRNPGNQA
700
AYEHFETMKN
710
QWIDNVEKMT
720
GLVDEAIDTK
730
SLLDASEEAI
740
KKDLDKCKVA
750
MANIQPQMLV
760
AGATSIARRA
770
NRILLVAKRE
780
VENSEDPKFR
790
EAVKAASDEL
800
SKTISPMVMD
810
AKAVAGNISD
820
PGLQKSFLDS
830
GYRILGAVAK
840
VREAFQPQEP
850
DFPPPPPDLE
860
QLRLTDELAP
870
PKPPLPEGEV
880
PPPRPPPPEE
890
KDEEFPEQKA
900
GEVINQPMMM
910
AARQLHDEAR
920
KWSSKGNDII
930
AAAKRMALLM
940
AEMSRLVRGG
950
SGTKRALIQC
960
AKDIAKASDE
970
VTRLAKEVAK
980
QCTDKRIRTN
990
LLQVCERIPT
1000
ISTQLKILST
1010
VKATMLGRTN
1020
ISDEESEQAT
1030
EMLVHNAQNL
1040
MQSVKETVRE
1050
AEAASIKIRT
1060
DAGFTLRWVR
KTPWYQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0043034 | costamere |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005916 | fascia adherens |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0090637 | inner dense plaque of desmosome |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0090636 | outer dense plaque of desmosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0061826 | podosome ring |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:1990357 | terminal web |
| Cellular Component | GO:0030018 | Z disc |
| Cellular Component | GO:0005915 | zonula adherens |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0045294 | alpha-catenin binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034333 | adherens junction assembly |
| Biological Process | GO:0043297 | apical junction assembly |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0090136 | epithelial cell-cell adhesion |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0002009 | morphogenesis of an epithelium |
| Biological Process | GO:0034394 | protein localization to cell surface |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
| Biological Process | GO:1904702 | regulation of protein localization to adherens junction |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.