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Overview

Uniprot IDQ659A1
Protein NameLittle elongation complex subunit 2
Gene NameICE2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
641 PIKRVYKKFDPVGEI

Function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III

Protein Sequence

10 MSSKMVISEP 20 GLNWDISPKN 30 GLKTFFSREN 40 YKDHSMAPSL 50 KELRVLSNRR 60 IGENLNASAS 70 SVENEPAVSS 80 ATQAKEKVKT 90 TIGMVLLPKP 100 RVPYPRFSRF 110 SQREQRSYVD 120 LLVKYAKIPA 130 NSKAVGINKN 140 DYLQYLDMKK 150 HVNEEVTEFL 160 KFLQNSAKKC 170 AQDYNMLSDD 180 ARLFTEKILR 190 ACIEQVKKYS 200 EFYTLHEVTS 210 LMGFFPFRVE 220 MGLKLEKTLL 230 ALGSVKYVKT 240 VFPSMPIKLQ 250 LSKDDIATIE 260 TSEQTAEAMH 270 YDISKDPNAE 280 KLVSRYHPQI 290 ALTSQSLFTL 300 LNNHGPTYKE 310 QWEIPVCIQV 320 IPVAGSKPVK 330 VIYINSPLPQ 340 KKMTMRERNQ 350 IFHEVPLKFM 360 MSKNTSVPVS 370 AVFMDKPEEF 380 ISEMDMSCEV 390 NECRKIESLE 400 NLYLDFDDDV 410 TELETFGVTT 420 TKVSKSPSPA 430 STSTVPNMTD 440 APTAPKAGTT 450 TVAPSAPDIS 460 ANSRSLSQIL 470 MEQLQKEKQL 480 VTGMDGGPEE 490 CKNKDDQGFE 500 SCEKVSNSDK 510 PLIQDSDLKT 520 SDALQLENSQ 530 EIETSNKNDM 540 TIDILHADGE 550 RPNVLENLDN 560 SKEKTVGSEA 570 AKTEDTVLCS 580 SDTDEECLII 590 DTECKNNSDG 600 KTAVVGSNLS 610 SRPASPNSSS 620 GQASVGNQTN 630 TACSPEESCV 640 LKKPIKRVYK 650 KFDPVGEILK 660 MQDELLKPIS 670 RKVPELPLMN 680 LENSKQPSVS 690 EQLSGPSDSS 700 SWPKSGWPSA 710 FQKPKGRLPY 720 ELQDYVEDTS 730 EYLAPQEGNF 740 VYKLFSLQDL 750 LLLVRCSVQR 760 IETRPRSKKR 770 KKIRRQFPVY 780 VLPKVEYQAC 790 YGVEALTESE 800 LCRLWTESLL 810 HSNSSFYVGH 820 IDAFTSKLFL 830 LEEITSEELK 840 EKLSALKISN 850 LFNILQHILK 860 KLSSLQEGSY 870 LLSHAAEDSS 880 LLIYKASDGK 890 VTRTAYNLYK 900 THCGLPGVPS 910 SLSVPWVPLD 920 PSLLLPYHIH 930 HGRIPCTFPP 940 KSLDTTTQQK 950 IGGTRMPTRS 960 HRNPVSMETK 970 SSCLPAQQVE 980 TEGVAPHKRK IT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0035363 histone locus body
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0008023 transcription elongation factor complex
Biological Process GO:1905382 positive regulation of snRNA transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0042796 snRNA transcription by RNA polymerase III

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.