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Overview

Uniprot ID	Q66GS9
Protein Name	Centrosomal protein of 135 kDa
Gene Name	CEP135
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
983	SLRELCIKLDSGKDI

Function

Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865)

Protein Sequence

10 MTTAVERKYI 20 NIRKRLDQLG 30 YRQTLTVECL 40 PLVEKLFSDL 50 VHTTESLRQS 60 KLSAVKAEKE 70 SANFDFVLEP 80 YKLENARLSR 90 ENNELYLELM 100 KLREHSDQHV 110 KELKTSLKKC 120 ARETADLKFL 130 NNQYAHKLKL 140 LEKESKAKNE 150 RIQQLQEKNL 160 HAVVQTPGGK 170 KRSIAFRRQR 180 MQIDEPVPPS 190 EVSSYPVPQP 200 DDPYIADLLQ 210 VADNRIQELQ 220 QEVHQLQEKL 230 AMMESGVRDY 240 SKQIELRERE 250 IERLSVALDG 260 GRSPDVLSLE 270 SRNKTNEKLI 280 AHLNIQVDFL 290 QQANKDLEKR 300 IRELMETKET 310 VTSEVVNLSN 320 KNEKLCQELT 330 EIDQLAQQLE 340 RHKEEVLETA 350 DKELGEAKKE 360 IKRKLSEMQD 370 LEETMAKLQL 380 ELNLCQKEKE 390 RLSDELLVKS 400 DLETVVHQLE 410 QEKQRLSKKV 420 ESFAVTERQL 430 TLEVERMRLE 440 HGIKRRDRSP 450 SRLDTFLKGI 460 EEERDYYKKE 470 LERLQHIIQR 480 RSCSTSYSAR 490 EKSSIFRTPE 500 KGDYNSEIHQ 510 ITRERDELQR 520 MLERFEKYME 530 DIQSNVKLLT 540 AERDKLSVLY 550 NEAQEELSAL 560 RKESTQTTAP 570 HNIVSLMEKE 580 KELALSDLRR 590 IMAEKEALRE 600 KLEHIEEVSL 610 FGKSELEKTI 620 EHLTCVNHQL 630 ESEKYELKSK 640 VLIMKETIES 650 LENKLKVQAQ 660 KFSHVAGDSS 670 HQKTEVNSLR 680 IVNEQLQRSV 690 DDYQHRLSIK 700 RGELESAQAQ 710 IKILEEKIDE 720 LNLKMTSQDE 730 EAHVMKKTIG 740 VIDKEKDFLQ 750 ETVDEKTEKI 760 ANLQENLANK 770 EKAVAQMKIM 780 ISECESSVNQ 790 LKETLVNRDR 800 EINSLRRQLD 810 AAHKELDEVG 820 RSREIAFKEN 830 RRLQDDLATM 840 ARENQEISLE 850 LEAAVQEKEE 860 MKSRVHKYIT 870 EVSRWESLMA 880 AKEKENQDLL 890 DRFQMLHNRA 900 EDWEVKAHQA 910 EGESSSVRLE 920 LLSIDTERRH 930 LRERVELLEK 940 EIQEHINAHH 950 AYESQISSMA 960 KAMSRLEEEL 970 RHQEDEKATV 980 LNDLSSLREL 990 CIKLDSGKDI 1000 MTQQLNSKNL 1010 EFERVVVELE 1020 NVKSESDLLK 1030 KQLSNERHTV 1040 KNLESLLATN 1050 RDKEFHSHLT 1060 SHEKDTEIQL 1070 LKEKLTLSES 1080 KLTSQSRENT 1090 MLRAKVAQLQ 1100 TDYDALKRQI 1110 STERYERERA 1120 IQEMRRHGLA 1130 TPPLSSTLRS 1140 PSHSPEHRNV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005814	centriole
Biological Process	GO:0007099	centriole replication
Biological Process	GO:0010457	centriole-centriole cohesion
Biological Process	GO:1904951	positive regulation of establishment of protein localization
Biological Process	GO:1902857	positive regulation of non-motile cilium assembly
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0015631	tubulin binding

Reference

PMID: N/A