Overview
| Uniprot ID | Q66GT5 |
|---|
| Protein Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
|---|
| Gene Name | Ptpmt1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 89 |
NTSKEWKKAGVEQLR |
Function
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity)
Protein Sequence
10
MAASAWLEAG
20
LARVLFYPTL
30
LYTVFRGRVR
40
GPAHRDWYHR
50
IDHTVLLGAL
60
PLKNMTRRLV
70
LDENVRGVIT
80
MNEEYETRFL
90
CNTSKEWKKA
100
GVEQLRLSTV
110
DMTGVPTLAN
120
LHKGVQFALK
130
YQALGQCVYV
140
HCKAGRSRSA
150
TMVAAYLIQV
160
HNWSPEEAIE
170
AIAKIRSHIS
180
IRPSQLEVLK
190
EFHKEITARA
AKN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0008962 |
phosphatidylglycerophosphatase activity |
| Molecular Function |
GO:0102091 |
phosphatidylinositol-5-phosphate phosphatase activity |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0004725 |
protein tyrosine phosphatase activity |
| Biological Process |
GO:0032049 |
cardiolipin biosynthetic process |
| Biological Process |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
| Biological Process |
GO:0061179 |
negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process |
GO:0046488 |
phosphatidylinositol metabolic process |
| Biological Process |
GO:2001242 |
regulation of intrinsic apoptotic signaling pathway |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.