Search Results
Overview
| Uniprot ID | Q66K74 |
|---|---|
| Protein Name | Microtubule-associated protein 1S |
| Gene Name | MAP1S |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 877 | NSRAAAPKATPVAAA |
| 885 | ATPVAAAKTKGLAGG |
Function
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity)
Protein Sequence
10
MAAVAGSGAA
20
AAPSSLLLVV
30
GSEFGSPGLL
40
TYVLEELERG
50
IRSWDVDPGV
60
CNLDEQLKVF
70
VSRHSATFSS
80
IVKGQRSLHH
90
RGDNLETLVL
100
LNPSDKSLYD
110
ELRNLLLDPA
120
SHKLLVLAGP
130
CLEETGELLL
140
QTGGFSPHHF
150
LQVLKDREIR
160
DILATTPPPV
170
QPPILTITCP
180
TFGDWAQLAP
190
AVPGLQGALR
200
LQLRLNPPAQ
210
LPNSEGLCEF
220
LEYVAESLEP
230
PSPFELLEPP
240
TSGGFLRLGR
250
PCCYIFPGGL
260
GDAAFFAVNG
270
FTVLVNGGSN
280
PKSSFWKLVR
290
HLDRVDAVLV
300
THPGADSLPG
310
LNSLLRRKLA
320
ERSEVAAGGG
330
SWDDRLRRLI
340
SPNLGVVFFN
350
ACEAASRLAR
360
GEDEAELALS
370
LLAQLGITPL
380
PLSRGPVPAK
390
PTVLFEKMGV
400
GRLDMYVLHP
410
PSAGAERTLA
420
SVCALLVWHP
430
AGPGEKVVRV
440
LFPGCTPPAC
450
LLDGLVRLQH
460
LRFLREPVVT
470
PQDLEGPGRA
480
ESKESVGSRD
490
SSKREGLLAT
500
HPRPGQERPG
510
VARKEPARAE
520
APRKTEKEAK
530
TPRELKKDPK
540
PSVSRTQPRE
550
VRRAASSVPN
560
LKKTNAQAAP
570
KPRKAPSTSH
580
SGFPPVANGP
590
RSPPSLRCGE
600
ASPPSAACGS
610
PASQLVATPS
620
LELGPIPAGE
630
EKALELPLAA
640
SSIPRPRTPS
650
PESHRSPAEG
660
SERLSLSPLR
670
GGEAGPDASP
680
TVTTPTVTTP
690
SLPAEVGSPH
700
STEVDESLSV
710
SFEQVLPPSA
720
PTSEAGLSLP
730
LRGPRARRSA
740
SPHDVDLCLV
750
SPCEFEHRKA
760
VPMAPAPASP
770
GSSNDSSARS
780
QERAGGLGAE
790
ETPPTSVSES
800
LPTLSDSDPV
810
PLAPGAADSD
820
EDTEGFGVPR
830
HDPLPDPLKV
840
PPPLPDPSSI
850
CMVDPEMLPP
860
KTARQTENVS
870
RTRKPLARPN
880
SRAAAPKATP
890
VAAAKTKGLA
900
GGDRASRPLS
910
ARSEPSEKGG
920
RAPLSRKSST
930
PKTATRGPSG
940
SASSRPGVSA
950
TPPKSPVYLD
960
LAYLPSGSSA
970
HLVDEEFFQR
980
VRALCYVISG
990
QDQRKEEGMR
1000
AVLDALLASK
1010
QHWDRDLQVT
1020
LIPTFDSVAM
1030
HTWYAETHAR
1040
HQALGITVLG
1050
SNSMVSMQDD
AFPACKVEF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:1990498 | mitotic spindle microtubule |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0071987 | WD40-repeat domain binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0016358 | dendrite development |
| Biological Process | GO:0051310 | metaphase chromosome alignment |
| Biological Process | GO:0034454 | microtubule anchoring at centrosome |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0047497 | mitochondrion transport along microtubule |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0031114 | regulation of microtubule depolymerization |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.