Search Results
Overview
| Uniprot ID | Q66LE6 |
|---|---|
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
| Gene Name | PPP2R2D |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 411 | CTGGKRRKDEISVDS |
Function
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity)
Protein Sequence
10
MAGAGGGGCP
20
AGGNDFQWCF
30
SQVKGAIDED
40
VAEADIISTV
50
EFNYSGDLLA
60
TGDKGGRVVI
70
FQREQENKSR
80
PHSRGEYNVY
90
STFQSHEPEF
100
DYLKSLEIEE
110
KINKIRWLPQ
120
QNAAHFLLST
130
NDKTIKLWKI
140
SERDKRAEGY
150
NLKDEDGRLR
160
DPFRITALRV
170
PILKPMDLMV
180
EASPRRIFAN
190
AHTYHINSIS
200
VNSDHETYLS
210
ADDLRINLWH
220
LEITDRSFNI
230
VDIKPANMEE
240
LTEVITAAEF
250
HPHQCNVFVY
260
SSSKGTIRLC
270
DMRSSALCDR
280
HSKFFEEPED
290
PSSRSFFSEI
300
ISSISDVKFS
310
HSGRYMMTRD
320
YLSVKVWDLN
330
MESRPVETHQ
340
VHEYLRSKLC
350
SLYENDCIFD
360
KFECCWNGSD
370
SAIMTGSYNN
380
FFRMFDRDTR
390
RDVTLEASRE
400
SSKPRASLKP
410
RKVCTGGKRR
420
KDEISVDSLD
430
FNKKILHTAW
440
HPVDNVIAVA
450
ATNNLYIFQD
KIN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000159 | protein phosphatase type 2A complex |
| Molecular Function | GO:0140767 | enzyme-substrate adaptor activity |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0010458 | exit from mitosis |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0051983 | regulation of chromosome segregation |
Reference
PMID: N/A