Search Results
Overview
| Uniprot ID | Q66PJ3 |
|---|---|
| Protein Name | ADP-ribosylation factor-like protein 6-interacting protein 4 |
| Gene Name | ARL6IP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 186 | ARQSIIRKVVDPETG |
| 199 | TGRTRLIKGDGEVLE |
| 211 | VLEEIVTKERHREIN |
Function
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA
Protein Sequence
10
MAHVGSRKRS
20
RSRSRSRGRG
30
SEKRKKKSRK
40
DTSRNCSAST
50
SQGRKASTAP
60
GAEASPSPCI
70
TERSKQKARR
80
RTRSSSSSSS
90
SSSSSSSSSS
100
SSSSSSSSDG
110
RKKRGKYKDK
120
RRKKKKKRKK
130
LKKKGKEKAE
140
AQQVEALPGP
150
SLDQWHRSAG
160
EEEDGPVLTD
170
EQKSRIQAMK
180
PMTKEEWDAR
190
QSIIRKVVDP
200
ETGRTRLIKG
210
DGEVLEEIVT
220
KERHREINKQ
230
ATRGDCLAFQ
MRAGLLP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0008380 | RNA splicing |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.