Search Results
Overview
| Uniprot ID | Q684M6 |
|---|---|
| Protein Name | Hsp90 co-chaperone Cdc37 |
| Gene Name | CDC37 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | EVREQKHKTFVEKYE |
| 156 | KHKTFVEKYEKQIKH |
| 229 | LELAKSLKVDPRACF |
| 45 | ERMEQFQKEKEELDR |
| 47 | MEQFQKEKEELDRGC |
| 69 | AECQRKLKELEVAEG |
| 95 | AEAQQLLKEERSWEQ |
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity
Protein Sequence
10
MVDYSVWDHI
20
EVSDDEDETH
30
PNIDTASLFR
40
WRHQARVERM
50
EQFQKEKEEL
60
DRGCRECKRK
70
VAECQRKLKE
80
LEVAEGEGGE
90
AELERLQAEA
100
QQLLKEERSW
110
EQKLEEMRKK
120
EKSMPWNVDT
130
LSKDGFSKSM
140
VNTKPEQAEE
150
ESEEVREQKH
160
KTFVEKYEKQ
170
IKHFGMLRRW
180
DDSQKYLSDN
190
VHLVCEETAN
200
YLVIWCIDLE
210
VEEKCALMEQ
220
VAHQTIVMQF
230
ILELAKSLKV
240
DPRACFRQFF
250
TKIKTADRQY
260
MEGFNDELEA
270
FKDRVRGRAK
280
LRIEKAMKEY
290
EEEERKKRLG
300
PGGLDPVEVY
310
ESLPEELQKC
320
FDAKDVQMLQ
330
DAISKMDPTD
340
AKYHMQRCID
350
SGLWVPNSKS
360
SEAKEGEEAG
370
PGDPLLEAAS
380
KSGDEKDVSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:1990565 | HSP90-CDC37 chaperone complex |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019887 | protein kinase regulator activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:1905091 | positive regulation of type 2 mitophagy |
| Biological Process | GO:0010608 | post-transcriptional regulation of gene expression |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.