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Overview

Uniprot ID	Q68CJ6
Protein Name	Nuclear GTPase SLIP-GC
Gene Name	NUGGC
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
369	PEYLRERKAGNQAIQ

Function

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity)

Protein Sequence

10 MAETKDVFGQ 20 EPHPVEDDLY 30 KERTRKRRKS 40 DRDQRFRAFP 50 SMEQSALKEY 60 EKLESRTRRV 70 LSNTYQKLIQ 80 SVFLDDSIPN 90 GVKYLINRLL 100 ALIEKPTVDP 110 IYIALFGSTG 120 AGKSSLINAI 130 IQQAMFLPVS 140 GESICTSCIV 150 QVSSGCCVQY 160 EAKIHLLSDQ 170 EWREELKNLT 180 KLLHRTEELS 190 REEADAWNRD 200 EAVEEATWKL 210 QMIYGNGAES 220 KNYEELLRAK 230 PKRKIPTSRV 240 ITLKAEEAEE 250 LSIKLDPYIR 260 TQRRDWDGEA 270 AEMRIWPLIK 280 HVEVTLPKSD 290 LIPEGVVLVD 300 IPGTGDFNSK 310 RDEMWKKTID 320 KCSVIWVISD 330 IERVSGGQAH 340 EDLLNESIKA 350 CQRGFCRDVA 360 LVVTKMDKLH 370 LPEYLRERKA 380 GNQAIQSQRE 390 AVLERNEMIK 400 LQRTRILKEK 410 LKRKLPADFK 420 VLEASDLVYT 430 VSAQEYWQQA 440 LLTEEETEIP 450 KLREYIRKSL 460 LDKKKRTVTK 470 YVTEAFGLLL 480 LTDSFNSTQN 490 LPNEHLHMSV 500 LRRFAEEKVE 510 LLEKAIAQCF 520 ACMEQPLQEG 530 VRTARTSYRC 540 ILRACLVRSK 550 GNQGFHQTLK 560 AVCLKNGIYA 570 SRTLARIDLN 580 EALTQPVYDQ 590 IDPVFGSIFR 600 TGKPTGSALM 610 PHIDAFKQSL 620 QEKMTEIGIR 630 SGWKYDSCKK 640 NFLIQEISAI 650 LGGLEDHILR 660 RKRRIYESLT 670 ASVQSDLKLC 680 YEEAAQITGK 690 KACERMKDAI 700 RRGVDRQVAE 710 GMFERAQERM 720 QHQFQQLKTG 730 IVEKVKGSIT 740 TMLALASSQG 750 DGLYKELADV 760 GSEYKEMEKL 770 HRSLREVAEN 780 ARLRKGMQEF 790 LLRASPSKAG PPGTSL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0033262	regulation of nuclear cell cycle DNA replication

Reference

PMID: N/A