Search Results

Overview

Uniprot IDQ68CK6
Protein NameAcyl-coenzyme A synthetase ACSM2B, mitochondrial
Gene NameACSM2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
153 LYRLQMSKAKAIVAG
415 GDIGIRVKPIRPIGI
432 GYVENPDKTAANIRG
539 KSVTAPYKYPRKIEF
557 LPKTVTGKIQRTKLR
569 KLRDKEWKMSGKARA
75 ALWWVNGKGKELMWN
77 WWVNGKGKELMWNFR

Function

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065, PubMed:12616642)

Protein Sequence

10 MHWLRKVQGL 20 CTLWGTQMSS 30 RTLYINSRQL 40 VSLQWGHQEV 50 PAKFNFASDV 60 LDHWADMEKA 70 GKRLPSPALW 80 WVNGKGKELM 90 WNFRELSENS 100 QQAANILSGA 110 CGLQRGDRVA 120 VMLPRVPEWW 130 LVILGCIRAG 140 LIFMPGTIQM 150 KSTDILYRLQ 160 MSKAKAIVAG 170 DEVIQEVDTV 180 ASECPSLRIK 190 LLVSEKSCDG 200 WLNFKKLLNE 210 ASTTHHCVET 220 GSQEASAIYF 230 TSGTSGLPKM 240 AEHSYSSLGL 250 KAKMDAGWTG 260 LQASDIMWTI 270 SDTGWILNIL 280 GSLLESWTLG 290 ACTFVHLLPK 300 FDPLVILKTL 310 SSYPIKSMMG 320 APIVYRMLLQ 330 QDLSSYKFPH 340 LQNCLAGGES 350 LLPETLENWR 360 AQTGLDIREF 370 YGQTETGLTC 380 MVSKTMKIKP 390 GYMGTAASCY 400 DVQVIDDKGN 410 VLPPGTEGDI 420 GIRVKPIRPI 430 GIFSGYVENP 440 DKTAANIRGD 450 FWLLGDRGIK 460 DEDGYFQFMG 470 RADDIINSSG 480 YRIGPSEVEN 490 ALMKHPAVVE 500 TAVISSPDPV 510 RGEVVKAFVI 520 LASQFLSHDP 530 EQLTKELQQH 540 VKSVTAPYKY 550 PRKIEFVLNL 560 PKTVTGKIQR 570 TKLRDKEWKM SGKARAQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0018858 benzoate-CoA ligase activity
Molecular Function GO:0016405 CoA-ligase activity
Molecular Function GO:0102391 decanoate-CoA ligase activity
Molecular Function GO:0015645 fatty acid ligase activity
Molecular Function GO:0004321 fatty-acyl-CoA synthase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006637 acyl-CoA metabolic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.