Search Results

Overview

Uniprot ID	Q68CP9
Protein Name	AT-rich interactive domain-containing protein 2
Gene Name	ARID2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1716	GSQKSSTKQPTVGGT
1731	SSTPRAQKAIVNHPS
706	PVTVIQSKAPIPCEV

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes

Protein Sequence

10 MANSTGKAPP 20 DERRKGLAFL 30 DELRQFHHSR 40 GSPFKKIPAV 50 GGKELDLHGL 60 YTRVTTLGGF 70 AKVSEKNQWG 80 EIVEEFNFPR 90 SCSNAAFALK 100 QYYLRYLEKY 110 EKVHHFGEDD 120 DEVPPGNPKP 130 QLPIGAIPSS 140 YNYQQHSVSD 150 YLRQSYGLSM 160 DFNSPNDYNK 170 LVLSLLSGLP 180 NEVDFAINVC 190 TLLSNESKHV 200 MQLEKDPKII 210 TLLLANAGVF 220 DDTLGSFSTV 230 FGEEWKEKTD 240 RDFVKFWKDI 250 VDDNEVRDLI 260 SDRNKSHEGT 270 SGEWIWESLF 280 HPPRKLGIND 290 IEGQRVLQIA 300 VILRNLSFEE 310 GNVKLLAANR 320 TCLRFLLLSA 330 HSHFISLRQL 340 GLDTLGNIAA 350 ELLLDPVDFK 360 TTHLMFHTVT 370 KCLMSRDRFL 380 KMRGMEILGN 390 LCKAEDNGVL 400 ICEYVDQDSY 410 REIICHLTLP 420 DVLLVISTLE 430 VLYMLTEMGD 440 VACTKIAKVE 450 KSIDMLVCLV 460 SMDIQMFGPD 470 ALAAVKLIEH 480 PSSSHQMLSE 490 IRPQAIEQVQ 500 TQTHVASAPA 510 SRAVVAQHVA 520 PPPGIVEIDS 530 EKFACQWLNA 540 HFEVNPDCSV 550 SRAEMYSEYL 560 STCSKLARGG 570 ILTSTGFYKC 580 LRTVFPNHTV 590 KRVEDSSSNG 600 QAHIHVVGVK 610 RRAIPLPIQM 620 YYQQQPVSTS 630 VVRVDSVPDV 640 SPAPSPAGIP 650 HGSQTIGNHF 660 QRTPVANQSS 670 NLTATQMSFP 680 VQGVHTVAQT 690 VSRIPQNPSP 700 HTHQQQNAPV 710 TVIQSKAPIP 720 CEVVKATVIQ 730 NSIPQTGVPV 740 SIAVGGGPPQ 750 SSVVQNHSTG 760 PQPVTVVNSQ 770 TLLHHPSVIP 780 QQSPLHTVVP 790 GQIPSGTPVT 800 VIQQAVPQSH 810 MFGRVQNIPA 820 CTSTVSQGQQ 830 LITTSPQPVQ 840 TSSQQTSAGS 850 QSQDTVIIAP 860 PQYVTTSASN 870 IVSATSVQNF 880 QVATGQMVTI 890 AGVPSPQASR 900 VGFQNIAPKP 910 LPSQQVSSTV 920 VQQPIQQPQQ 930 PTQQSVVIVS 940 QPAQQGQTYA 950 PAIHQIVLAN 960 PAALPAGQTV 970 QLTGQPNITP 980 SSSPSPVPAT 990 NNQVPTAMSS 1000 SSTPQSQGPP 1010 PTVSQMLSVK 1020 RQQQQQHSPA 1030 PPPQQVQVQV 1040 QQPQQVQMQV 1050 QPQQSNAGVG 1060 QPASGESSLI 1070 KQLLLPKRGP 1080 STPGGKLILP 1090 APQIPPPNNA 1100 RAPSPQVVYQ 1110 VASNQAAGFG 1120 VQGQTPAQQL 1130 LVGQQNVQLV 1140 PSAMPPSGGV 1150 QTVPISNLQI 1160 LPGPLISNSP 1170 ATIFQGTSGN 1180 QVTITVVPNT 1190 SFAPATVSQG 1200 NATQLIAPAG 1210 ITMSGTQTGV 1220 GLPVQTLPAT 1230 QASPAGQSSC 1240 TTATPPFKGD 1250 KIICQKEEEA 1260 KEATGLHVHE 1270 RKIEVMENPS 1280 CRRGATNTSN 1290 GDTKENEMHV 1300 GSLLNGRKYS 1310 DSSLPPSNSG 1320 KIQSETNQCS 1330 LISNGPSLEL 1340 GENGASGKQN 1350 SEQIDMQDIK 1360 SDLRKPLVNG 1370 ICDFDKGDGS 1380 HLSKNIPNHK 1390 TSNHVGNGEI 1400 SPMEPQGTLD 1410 ITQQDTAKGD 1420 QLERISNGPV 1430 LTLGGSSVSS 1440 IQEASNAATQ 1450 QFSGTDLLNG 1460 PLASSLNSDV 1470 PQQRPSVVVS 1480 PHSTTSVIQG 1490 HQIIAVPDSG 1500 SKVSHSPALS 1510 SDVRSTNGTA 1520 ECKTVKRPAE 1530 DTDRETVAGI 1540 PNKVGVRIVT 1550 ISDPNNAGCS 1560 ATMVAVPAGA 1570 DPSTVAKVAI 1580 ESAVQQKQQH 1590 PPTYVQNVVP 1600 QNTPMPPSPA 1610 VQVQGQPNSS 1620 QPSPFSGSSQ 1630 PGDPMRKPGQ 1640 NFMCLWQSCK 1650 KWFQTPSQVF 1660 YHAATEHGGK 1670 DVYPGQCLWE 1680 GCEPFQRQRF 1690 SFITHLQDKH 1700 CSKDALLAGL 1710 KQDEPGQAGS 1720 QKSSTKQPTV 1730 GGTSSTPRAQ 1740 KAIVNHPSAA 1750 LMALRRGSRN 1760 LVFRDFTDEK 1770 EGPITKHIRL 1780 TAALILKNIG 1790 KYSECGRRLL 1800 KRHENNLSVL 1810 AISNMEASST 1820 LAKCLYELNF 1830 TVQSKEQEKD SEMLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0006337	nucleosome disassembly
Biological Process	GO:0045597	positive regulation of cell differentiation
Biological Process	GO:2000781	positive regulation of double-strand break repair
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination
Biological Process	GO:0045663	positive regulation of myoblast differentiation
Biological Process	GO:0045582	positive regulation of T cell differentiation
Biological Process	GO:0070316	regulation of G0 to G1 transition
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition
Biological Process	GO:2000819	regulation of nucleotide-excision repair
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0016514	SWI/SNF complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006338	chromatin remodeling

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.