Search Results

Overview

Uniprot IDQ68CQ4
Protein NameU3 small nucleolar RNA-associated protein 25 homolog
Gene NameUTP25
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
18 QLLNTLTKKQKKHLR
19 LLNTLTKKQKKHLRD

Function

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329)

Protein Sequence

10 MGKRGSRSQS 20 QLLNTLTKKQ 30 KKHLRDFGEE 40 HPFYDRVSRK 50 EAKPQICQLS 60 ESSDSSDSES 70 DSESEPQQVS 80 GYHRLLATLK 90 NVSEEEEEDE 100 EEEEEEDSIV 110 DDAEMNDEDG 120 GSDVSVEEEM 130 AAESTESPEN 140 VALSADPEGK 150 EDGEEPPGTS 160 QTSPEEFTDA 170 KHESLFSLET 180 NFLEEESGDN 190 SSLKASQDPF 200 LQHVNKELKE 210 KAIQAVATNP 220 KTTHELKWPI 230 LGQLFFSSKF 240 QKLETFKPPK 250 DIDLKSLHLQ 260 KPLESTWTKT 270 NSQFLSGPQK 280 SSSPFTPLQK 290 ELFLIMNSYR 300 DLFYPERTAL 310 KNGEEIRHVY 320 CLHVINHILK 330 ANAQVLGNNS 340 RRRSQKFGVG 350 DDDDFRDQGL 360 TRPKVLIVVP 370 FREAALRVVQ 380 LFISLLEGDS 390 KKKIIVSNKK 400 RFQGEYGSDP 410 EERPPNLKRP 420 EDYEAVFVGN 430 IDDHFRIGVA 440 ILQRSIRLYA 450 PFYSSDILIA 460 SPLGLRTIIG 470 GEGEKKRDFD 480 FLSSIELLII 490 DQADIYLMQN 500 WEHVLHLMNH 510 MNLLPLDSHG 520 VDFSRVRMWS 530 LNNWSKYYRQ 540 TLLFGALQDA 550 QINSVFNKYC 560 VNMQGQVAVR 570 NVPMTGSISH 580 VLVQLPHVFQ 590 RMEAENLASV 600 IDARFNFFVN 610 KILPQYRDAV 620 MSHTLIYIPS 630 YFDFVRLRNY 640 FKKEELNFTH 650 ICEYTQKSGV 660 SRARHFFLQG 670 EKQFLLFTER 680 FHFYKRYTIK 690 GIRNLIFYEL 700 PTYPHFYSEI 710 CNMLRATNRG 720 EEATWTCTVL 730 YSKYDAQRLA 740 AVVGVERAAQ 750 MLQSNKNVHL FITGEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0019843 rRNA binding
Molecular Function GO:0034511 U3 snoRNA binding
Biological Process GO:0048568 embryonic organ development
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0040019 positive regulation of embryonic development
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0031648 protein destabilization
Biological Process GO:1902570 protein localization to nucleolus

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.