Search Results

Overview

Uniprot ID	Q68D06
Protein Name	Schlafen family member 13
Gene Name	SLFN13
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
174	NEGSPPSKIMKAVYQ

Function

Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550)

Protein Sequence

10 MEANHCSLGV 20 YPSYPDLVID 30 VGEVTLGEEN 40 RKKLQKTQRD 50 QERARVIRAA 60 CALLNSGGGV 70 IQMEMANRDE 80 RPTEMGLDLE 90 ESLRKLIQYP 100 YLQAFFETKQ 110 HGRCFYIFVK 120 SWSGDPFLKD 130 GSFNSRICSL 140 SSSLYCRSGT 150 SVLHMNSRQA 160 FDFLKTKERQ 170 SKYNLINEGS 180 PPSKIMKAVY 190 QNISESNPAY 200 EVFQTDTIEY 210 GEILSFPESP 220 SIEFKQFSTK 230 HIQQYVENII 240 PEYISAFANT 250 EGGYLFIGVD 260 DKSRKVLGCA 270 KEQVDPDSLK 280 NVIARAISKL 290 PIVHFCSSKP 300 RVEYSTKIVE 310 VFCGKELYGY 320 LCVIKVKAFC 330 CVVFSEAPKS 340 WMVREKYIRP 350 LTTEEWVEKM 360 MDADPEFPPD 370 FAEAFESQLS 380 LSDSPSLCRP 390 VYSKKGLEHK 400 ADLQQHLFPV 410 PPGHLECTPE 420 SLWKELSLQH 430 EGLKELIHKQ 440 MRPFSQGIVI 450 LSRSWAVDLN 460 LQEKPGVICD 470 ALLIAQNSTP 480 ILYTILREQD 490 AEGQDYCTRT 500 AFTLKQKLVN 510 MGGYTGKVCV 520 RAKVLCLSPE 530 SSAEALEAAV 540 SPMDYPASYS 550 LAGTQHMEAL 560 LQSLVIVLLG 570 FRSLLSDQLG 580 CEVLNLLTAQ 590 QYEIFSRSLR 600 KNRELFVHGL 610 PGSGKTIMAM 620 KIMEKIRNVF 630 HCEAHRILYV 640 CENQPLRNFI 650 SDRNICRAET 660 RETFLREKFE 670 HIQHIVIDEA 680 QNFRTEDGDW 690 YRKAKTITQR 700 EKDCPGVLWI 710 FLDYFQTSHL 720 GHSGLPPLSA 730 QYPREELTRV 740 VRNADEIAEY 750 IQQEMQLIIE 760 NPPINIPHGY 770 LAILSEAKWV 780 PGVPGNTKII 790 KNFTLEQIVT 800 YVADTCRCFF 810 ERGYSPKDVA 820 VLVSTVTEVE 830 QYQSKLLKAM 840 RKKMVVQLSD 850 ACDMLGVHIV 860 LDSVRRFSGL 870 ERSIVFGIHP 880 RTADPAILPN 890 ILICLASRAK QHLYIFL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0004521	RNA endonuclease activity
Molecular Function	GO:0000049	tRNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0016075	rRNA catabolic process
Biological Process	GO:0016078	tRNA decay

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.