Overview
| Uniprot ID | Q68D10 |
|---|
| Protein Name | Protein SPT2 homolog |
|---|
| Gene Name | SPTY2D1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 12 |
EILMIASKGQGVNNV |
| 161 |
SKPKVPLKSAPPPMN |
| 241 |
QKESVGTKLSKGSGD |
| 416 |
ERSISGSKKPTNDSN |
| 545 |
VSETISSKNIISRSS |
Function
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026)
Protein Sequence
10
MDFREILMIA
20
SKGQGVNNVP
30
KRYSLAVGPP
40
KKDPKVKGVQ
50
SAAVQAFLKR
60
KEEELRRKAL
70
EEKRRKEELV
80
KKRIELKHDK
90
KARAMAKRTK
100
DNFHGYNGIP
110
IEEKSKKRQA
120
TESHTSQGTD
130
REYEMEEENE
140
FLEYNHAESE
150
QEYEEEQEPP
160
KVESKPKVPL
170
KSAPPPMNFT
180
DLLRLAEKKQ
190
FEPVEIKVVK
200
KSEERPMTAE
210
ELREREFLER
220
KHRRKKLETD
230
GKLPPTVSKK
240
APSQKESVGT
250
KLSKGSGDRH
260
PSSKGMPLPH
270
AEKKSRPSMA
280
NEKHLALSSS
290
KSMPGERIKA
300
GSGNSSQPSL
310
REGHDKPVFN
320
GAGKPHSSTS
330
SPSVPKTSAS
340
RTQKSAVEHK
350
AKKSLSHPSH
360
SRPGPMVTPH
370
NKAKSPGVRQ
380
PGSSSSSAPG
390
QPSTGVARPT
400
VSSGPVPRRQ
410
NGSSSSGPER
420
SISGSKKPTN
430
DSNPSRRTVS
440
GTCGPGQPAS
450
SSGGPGRPIS
460
GSVSSARPLG
470
SSRGPGRPVS
480
SPHELRRPVS
490
GLGPPGRSVS
500
GPGRSISGSI
510
PAGRTVSNSV
520
PGRPVSSLGP
530
GQTVSSSGPT
540
IKPKCTVVSE
550
TISSKNIISR
560
SSNGQMNGMK
570
PPLSGYRAAQ
580
GPQRLPFPTG
590
YKRQREYEEE
600
DDDDDEYDSE
610
MEDFIEDEGE
620
PQEEISKHIR
630
EIFGYDRKKY
640
KDESDYALRY
650
MESSWKEQQK
660
EEAKSLRLGM
670
QEDLEEMRRE
680
EEEMQRRRAK
KLKRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0140713 |
histone chaperone activity |
| Molecular Function |
GO:0001042 |
RNA polymerase I core binding |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0006334 |
nucleosome assembly |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0006360 |
transcription by RNA polymerase I |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.