Search Results

Overview

Uniprot IDQ68DE3
Protein NameBasic helix-loop-helix domain-containing protein USF3
Gene NameUSF3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
52 IPCSPALKQSKNMIL

Function

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties

Protein Sequence

10 MPEMTENETP 20 TKKQHRKKNR 30 ETHNAVERHR 40 KKKINAGINR 50 IGELIPCSPA 60 LKQSKNMILD 70 QAFKYITELK 80 RQNDELLLNG 90 GNNEQAEEIK 100 KLRKQLEEIQ 110 KENGRYIELL 120 KANDICLYDD 130 PTIHWKGNLK 140 NSKVSVVIPS 150 DQVQKKIIVY 160 SNGNQPGGNS 170 QGTAVQGITF 180 NVSHNLQKQT 190 ANVVPVQRTC 200 NLVTPVSISG 210 VYPSENKPWH 220 QTTVPALATN 230 QPVPLCLPAA 240 ISAQSILELP 250 TSESESNVLG 260 ATSGSLIAVS 270 IESEPHQHHS 280 LHTCLNDQNS 290 SENKNGQENP 300 KVLKKMTPCV 310 TNIPHSSSAT 320 ATKVHHGNKS 330 CLSIQDFRGD 340 FQNTFVVSVT 350 TTVCSQPPRT 360 AGDSSPMSIS 370 KSADLTSTAT 380 VVASSAPGVG 390 KATIPISTLS 400 GNPLDNGWTL 410 SCSLPSSSVS 420 TSDLKNINSL 430 TRISSAGNTQ 440 TTWTTLQLAG 450 NTIQPLSQTP 460 SSAVTPVLNE 470 SGTSPTTSNH 480 SRYVATDINL 490 NNSFPADGQP 500 VEQVVVTLPS 510 CPSLPMQPLI 520 AQPQVKSQPP 530 KNILPLNSAM 540 QVIQMAQPVG 550 SAVNSAPTNQ 560 NVIILQPPST 570 TPCPTVMRAE 580 VSNQTVGQQI 590 VIIQAANQNP 600 LPLLPAPPPG 610 SVRLPINGAN 620 TVIGSNNSVQ 630 NVPTPQTFGG 640 KHLVHILPRP 650 SSLSASNSTQ 660 TFSVTMSNQQ 670 PQTISLNGQL 680 FALQPVMSSS 690 GTTNQTPMQI 700 IQPTTSEDPN 710 TNVALNTFGA 720 LASLNQSISQ 730 MAGQSCVQLS 740 ISQPANSQTA 750 ANSQTTTANC 760 VSLTTTAAPP 770 VTTDSSATLA 780 STYNLVSTSS 790 MNTVACLPNM 800 KSKRLNKKPG 810 GRKHLAANKS 820 ACPLNSVRDV 830 SKLDCPNTEG 840 SAEPPCNDGL 850 LESFPAVLPS 860 VSVSQANSVS 870 VSASHSLGVL 880 SSESLIPESV 890 SKSKSAEKSS 900 PPSQESVTSE 910 HFAMAAAKSK 920 DSTPNLQQET 930 SQDKPPSSLA 940 LSDAAKPCAS 950 ANVLIPSPSD 960 PHILVSQVPG 970 LSSTTSTTST 980 DCVSEVEIIA 990 EPCRVEQDSS 1000 DTMQTTGLLK 1010 GQGLTTLLSD 1020 LAKKKNPQKS 1030 SLSDQMDHPD 1040 FSSENPKIVD 1050 SSVNLHPKQE 1060 LLLMNNDDRD 1070 PPQHHSCLPD 1080 QEVINGSLIN 1090 GRQADSPMST 1100 SSGSSRSFSV 1110 ASMLPETTRE 1120 DVTSNATTNT 1130 CDSCTFVEQT 1140 DIVALAARAI 1150 FDQENLEKGR 1160 VGLQADIREV 1170 ASKPSEASLL 1180 EGDPPFKSQI 1190 PKESGTGQAE 1200 ATPNEFNSQG 1210 SIEATMERPL 1220 EKPSCSLGIK 1230 TSNASLQDST 1240 SQPPSITSLS 1250 VNNLIHQSSI 1260 SHPLASCAGL 1270 SPTSEQTTVP 1280 ATVNLTVSSS 1290 SYGSQPPGPS 1300 LMTEYSQEQL 1310 NTMTSTIPNS 1320 QIQEPLLKPS 1330 HESRKDSAKR 1340 AVQDDLLLSS 1350 AKRQKHCQPA 1360 PLRLESMSLM 1370 SRTPDTISDQ 1380 TQMMVSQIPP 1390 NSSNSVVPVS 1400 NPAHGDGLTR 1410 LFPPSNNFVT 1420 PALRQTEVQC 1430 GSQPSVAEQQ 1440 QTQASQHLQA 1450 LQQHVPAQGV 1460 SHLHSNHLYI 1470 KQQQQQQQQQ 1480 QQQQQQQQAG 1490 QLRERHHLYQ 1500 MQHHVPHAES 1510 SVHSQPHNVH 1520 QQRTLQQEVQ 1530 MQKKRNLVQG 1540 TQTSQLSLQP 1550 KHHGTDQSRS 1560 KTGQPHPHHQ 1570 QMQQQMQQHF 1580 GSSQTEKSCE 1590 NPSTSRNHHN 1600 HPQNHLNQDI 1610 MHQQQDVGSR 1620 QQGSGVSSEH 1630 VSGHNPMQRL 1640 LTSRGLEQQM 1650 VSQPSIVTRS 1660 SDMTCTPHRP 1670 ERNRVSSYSA 1680 EALIGKTSSN 1690 SEQRMGISIQ 1700 GSRVSDQLEM 1710 RSYLDVPRNK 1720 SLAIHNMQGR 1730 VDHTVASDIR 1740 LSDCQTFKPS 1750 GASQQPQSNF 1760 EVQSSRNNEI 1770 GNPVSSLRSM 1780 QSQAFRISQN 1790 TGPPPIDRQK 1800 RLSYPPVQSI 1810 PTGNGIPSRD 1820 SENTCHQSFM 1830 QSLLAPHLSD 1840 QVIGSQRSLS 1850 EHQRNTQCGP 1860 SSAIEYNCPP 1870 THENVHIRRE 1880 SESQNRESCD 1890 MSLGAINTRN 1900 STLNIPFSSS 1910 SSSGDIQGRN 1920 TSPNVSVQKS 1930 NPMRITESHA 1940 TKGHMNPPVT 1950 TNMHGVARPA 1960 LPHPSVSHGN 1970 GDQGPAVRQA 1980 NSSVPQRSRH 1990 PLQDSSGSKI 2000 RQPERNRSGN 2010 QRQSTVFDPS 2020 LPHLPLSTGG 2030 SMILGRQQPA 2040 TEKRGSIVRF 2050 MPDSPQVPND 2060 NSGPDQHTLS 2070 QNFGFSFIPE 2080 GGMNPPINAN 2090 ASFIPQVTQP 2100 SATRTPALIP 2110 VDPQNTLPSF 2120 YPPYSPAHPT 2130 LSNDISIPYF 2140 PNQMFSNPST 2150 EKVNSGSLNN 2160 RFGSILSPPR 2170 PVGFAQPSFP 2180 LLPDMPPMHM 2190 TNSHLSNFNM 2200 TSLFPEIATA 2210 LPDGSAMSPL 2220 LTIANSSASD 2230 SSKQSSNRPA 2240 HNISHILGHD CSSAV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0010719 negative regulation of epithelial to mesenchymal transition
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.