Search Results

Overview

Uniprot IDQ68DK7
Protein NameMale-specific lethal 1 homolog
Gene NameMSL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
346 ERKTPVKKLAPEFSK
353 KLAPEFSKVKTKTPK
355 APEFSKVKTKTPKHS
9 TMRSAVFKAAAAPAG

Function

Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816)

Protein Sequence

10 MTMRSAVFKA 20 AAAPAGGNPE 30 QRLDYERAAA 40 LGGPEDEPGA 50 AEAHFLPRHR 60 KLKEPGPPLA 70 SSQGGSPAPS 80 PAGCGGKGRG 90 LLLPAGAAPG 100 QQEESWGGSV 110 PLPCPPPATK 120 QAGIGGEPAA 130 AGAGCSPRPK 140 YQAVLPIQTG 150 SLVAAAKEPT 160 PWAGDKGGAA 170 SPAATASDPA 180 GPPPLPLPGP 190 PPLAPTATAG 200 TLAASEGRWK 210 SMRKSPLGGG 220 GGSGASSQAA 230 CLKQILLLQL 240 DLIEQQQQQL 250 QAKEKEIEEL 260 KSERDTLLAR 270 IERMERRMQL 280 VKKDNEKERH 290 KLFQGYETEE 300 REETELSEKI 310 KLECQPELSE 320 TSQTLPPKPF 330 SCGRSGKGHK 340 RKSPFGSTER 350 KTPVKKLAPE 360 FSKVKTKTPK 370 HSPIKEEPCG 380 SLSETVCKRE 390 LRSQETPEKP 400 RSSVDTPPRL 410 STPQKGPSTH 420 PKEKAFSSEI 430 EDLPYLSTTE 440 MYLCRWHQPP 450 PSPLPLRESS 460 PKKEETVARC 470 LMPSSVAGET 480 SVLAVPSWRD 490 HSVEPLRDPN 500 PSDLLENLDD 510 SVFSKRHAKL 520 ELDEKRRKRW 530 DIQRIREQRI 540 LQRLQLRMYK 550 KKGIQESEPE 560 VTSFFPEPDD 570 VESLMITPFL 580 PVVAFGRPLP 590 KLTPQNFELP 600 WLDERSRCRL 610 EIQKKQTPHR TCRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072487 MSL complex
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0045893 positive regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.