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Overview

Uniprot IDQ68EM7
Protein NameRho GTPase-activating protein 17
Gene NameARHGAP17
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
9 KKQFNRMKQLANQTV

Function

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1

Protein Sequence

10 MKKQFNRMKQ 20 LANQTVGRAE 30 KTEVLSEDLL 40 QIERRLDTVR 50 SICHHSHKRL 60 VACFQGQHGT 70 DAERRHKKLP 80 LTALAQNMQE 90 ASTQLEDSLL 100 GKMLETCGDA 110 ENQLALELSQ 120 HEVFVEKEIV 130 DPLYGIAEVE 140 IPNIQKQRKQ 150 LARLVLDWDS 160 VRARWNQAHK 170 SSGTNFQGLP 180 SKIDTLKEEM 190 DEAGNKVEQC 200 KDQLAADMYN 210 FMAKEGEYGK 220 FFVTLLEAQA 230 DYHRKALAVL 240 EKTLPEMRAH 250 QDKWAEKPAF 260 GTPLEEHLKR 270 SGREIALPIE 280 ACVMLLLETG 290 MKEEGLFRIG 300 AGASKLKKLK 310 AALDCSTSHL 320 DEFYSDPHAV 330 AGALKSYLRE 340 LPEPLMTFNL 350 YEEWTQVASV 360 QDQDKKLQDL 370 WRTCQKLPPQ 380 NFVNFRYLIK 390 FLAKLAQTSD 400 VNKMTPSNIA 410 IVLGPNLLWA 420 RNEGTLAEMA 430 AATSVHVVAV 440 IEPIIQHADW 450 FFPEEVEFNV 460 SEAFVPLTTP 470 SSNHSFHTGN 480 DSDSGTLERK 490 RPASMAVMEG 500 DLVKKESFGV 510 KLMDFQAHRR 520 GGTLNRKHIS 530 PAFQPPLPPT 540 DGSTVVPAGP 550 EPPPQSSRAE 560 SSSGGGTVPS 570 SAGILEQGPS 580 PGDGSPPKPK 590 DPVSAAVPAP 600 GRNNSQIASG 610 QNQPQAAAGS 620 HQLSMGQPHN 630 AAGPSPHTLR 640 RAVKKPAPAP 650 PKPGNPPPGH 660 PGGQSSSGTS 670 QHPPSLSPKP 680 PTRSPSPPTQ 690 HTGQPPGQPS 700 APSQLSAPRR 710 YSSSLSPIQA 720 PNHPPPQPPT 730 QATPLMHTKP 740 NSQGPPNPMA 750 LPSEHGLEQP 760 SHTPPQTPTP 770 PSTPPLGKQN 780 PSLPAPQTLA 790 GGNPETAQPH 800 AGTLPRPRPV 810 PKPRNRPSVP 820 PPPQPPGVHS 830 AGDSSLTNTA 840 PTASKIVTDS 850 NSRVSEPHRS 860 IFPEMHSDSA 870 SKDVPGRILL 880 DIDNDTESTA L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:0051058 negative regulation of small GTPase mediated signal transduction
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0035020 regulation of Rac protein signal transduction
Biological Process GO:0007165 signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.