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Overview

Uniprot IDQ69YH5
Protein NameCell division cycle-associated protein 2
Gene NameCDCA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
200 FPAVLSSKRRRISYQ
332 FVLRSVLKKPSVKMC
79 FVRNSAGKSSSYLKK
993 TKATSQFKGYRRRSS

Function

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phosphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates

Protein Sequence

10 MDANSKDKPP 20 ETKESAMNNA 30 GNASFILGTG 40 KIVTPQKHAE 50 LPPNPCTPDT 60 FKSPLNFSTV 70 TVEQLGITPE 80 SFVRNSAGKS 90 SSYLKKCRRR 100 SAVGARGSPE 110 TNHLIRFIAR 120 QQNIKNARKS 130 PLAQDSPSQG 140 SPALYRNVNT 150 LRERISAFQS 160 AFHSIKENEK 170 MTGCLEFSEA 180 GKESEMTDLT 190 RKEGLSACQQ 200 SGFPAVLSSK 210 RRRISYQRDS 220 DENLTDAEGK 230 VIGLQIFNID 240 TDRACAVETS 250 VDLSEISSKL 260 GSTQSGFLVE 270 ESLPLSELTE 280 TSNALKVADC 290 VVGKGSSDAV 300 SPDTFTAEVS 310 SDAVPDVRSP 320 ATPACRRDLP 330 TPKTFVLRSV 340 LKKPSVKMCL 350 ESLQEHCNNL 360 YDDDGTHPSL 370 ISNLPNCCKE 380 KEAEDEENFE 390 APAFLNMRKR 400 KRVTFGEDLS 410 PEVFDESLPA 420 NTPLRKGGTP 430 VCKKDFSGLS 440 SLLLEQSPVP 450 EPLPQPDFDD 460 KGENLENIEP 470 LQVSFAVLSS 480 PNKSSISETL 490 SGTDTFSSSN 500 NHEKISSPKV 510 GRITRTSNRR 520 NQLVSVVEES 530 VCNLLNTEVQ 540 PCKEKKINRR 550 KSQETKCTKR 560 ALPKKSQVLK 570 SCRKKKGKGK 580 KSVQKSLYGE 590 RDIASKKPLL 600 SPIPELPEVP 610 EMTPSIPSIR 620 RLGSGYFSSN 630 GKLEEVKTPK 640 NPVKRKDLLR 650 HDPDLHMHQG 660 YDKYDVSEFC 670 SYIKSSSSLG 680 NATSDEDPNT 690 NIMNINENKN 700 IPKAKNKSES 710 ENEPKAGTDS 720 PVSCASVTEE 730 RVASDSPKPA 740 LTLQQGQEFS 750 AGGQNAENLC 760 QFFKISPDLN 770 IKCERKDDFL 780 GAAEGKLQCN 790 RLMPNSQKDC 800 HCLGDVLIEN 810 TKESKSQSED 820 LGRKPMESSS 830 VVSCRDRKDR 840 RRSMCYSDGR 850 SLHLEKNGNH 860 TPSSSVGSSV 870 EISLENSELF 880 KDLSDAIEQT 890 FQRRNSETKV 900 RRSTRLQKDL 910 ENEGLVWISL 920 PLPSTSQKAK 930 RRTICTFDSS 940 GFESMSPIKE 950 TVSSRQKPQM 960 APPVSDPENS 970 QGPAAGSSDE 980 PGKRRKSFCI 990 STLANTKATS 1000 QFKGYRRRSS 1010 LNGKGESSLT 1020 ALERIEHNGE RKQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0019888 protein phosphatase regulator activity
Biological Process GO:0051301 cell division
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0007088 regulation of mitotic nuclear division

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.