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Overview

Uniprot ID	Q69YN4
Protein Name	Protein virilizer homolog
Gene Name	VIRMA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1613	SEYIEPAKRAHVVPP
1679	PPPKRPLKVSQKISS
1713	FFTPPASKGNYSRRE

Function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755)

Protein Sequence

10 MAVDSAMELL 20 FLDTFKHPSA 30 EQSSHIDVVR 40 FPCVVYINEV 50 RVIPPGVRAH 60 SSLPDNRAYG 70 ETSPHTFQLD 80 LFFNNVSKPS 90 APVFDRLGSL 100 EYDENTSIIF 110 RPNSKVNTDG 120 LVLRGWYNCL 130 TLAIYGSVDR 140 VISHDRDSPP 150 PPPPPPPPPQ 160 PQPSLKRNPK 170 HADGEKEDQF 180 NGSPPRPQPR 190 GPRTPPGPPP 200 PDDDEDDPVP 210 LPVSGDKEED 220 APHREDYFEP 230 ISPDRNSVPQ 240 EGQYSDEGEV 250 EEEQQEEGEE 260 DEDDVDVEEE 270 EDEDEDDRRT 280 VDSIPEEEEE 290 DEEEEGEEDE 300 EGEGDDGYEQ 310 ISSDEDGIAD 320 LERETFKYPN 330 FDVEYTAEDL 340 ASVPPMTYDP 350 YDRELVPLLY 360 FSCPYKTTFE 370 IEISRMKDQG 380 PDKENSGAIE 390 ASVKLTELLD 400 LYREDRGAKW 410 VTALEEIPSL 420 IIKGLSYLQL 430 KNTKQDSLGQ 440 LVDWTMQALN 450 LQVALRQPIA 460 LNVRQLKAGT 470 KLVSSLAECG 480 AQGVTGLLQA 490 GVISGLFELL 500 FADHVSSSLK 510 LNAFKALDSV 520 ISMTEGMEAF 530 LRGRQNEKSG 540 YQKLLELILL 550 DQTVRVVTAG 560 SAILQKCHFY 570 EVLSEIKRLG 580 DHLAEKTSSL 590 PNHSEPDHDT 600 DAGLERTNPE 610 YENEVEASMD 620 MDLLESSNIS 630 EGEIERLINL 640 LEEVFHLMET 650 APHTMIQQPV 660 KSFPTMARIT 670 GPPERDDPYP 680 VLFRYLHSHH 690 FLELVTLLLS 700 IPVTSAHPGV 710 LQATKDVLKF 720 LAQSQKGLLF 730 FMSEYEATNL 740 LIRALCHFYD 750 QDEEEGLQSD 760 GVIDDAFALW 770 LQDSTQTLQC 780 ITELFSHFQR 790 CTASEETDHS 800 DLLGTLHNLY 810 LITFNPVGRS 820 AVGHVFSLEK 830 NLQSLITLME 840 YYSKEALGDS 850 KSKKSVAYNY 860 ACILILVVVQ 870 SSSDVQMLEQ 880 HAASLLKLCK 890 ADENNAKLQE 900 LGKWLEPLKN 910 LRFEINCIPN 920 LIEYVKQNID 930 NLMTPEGVGL 940 TTALRVLCNV 950 ACPPPPVEGQ 960 QKDLKWNLAV 970 IQLFSAEGMD 980 TFIRVLQKLN 990 SILTQPWRLH 1000 VNMGTTLHRV 1010 TTISMARCTL 1020 TLLKTMLTEL 1030 LRGGSFEFKD 1040 MRVPSALVTL 1050 HMLLCSIPLS 1060 GRLDSDEQKI 1070 QNDIIDILLT 1080 FTQGVNEKLT 1090 ISEETLANNT 1100 WSLMLKEVLS 1110 SILKVPEGFF 1120 SGLILLSELL 1130 PLPLPMQTTQ 1140 VIEPHDISVA 1150 LNTRKLWSMH 1160 LHVQAKLLQE 1170 IVRSFSGTTC 1180 QPIQHMLRRI 1190 CVQLCDLASP 1200 TALLIMRTVL 1210 DLIVEDLQST 1220 SEDKEKQYTS 1230 QTTRLLALLD 1240 ALASHKACKL 1250 AILHLINGTI 1260 KGDERYAEIF 1270 QDLLALVRSP 1280 GDSVIRQQCV 1290 EYVTSILQSL 1300 CDQDIALILP 1310 SSSEGSISEL 1320 EQLSNSLPNK 1330 ELMTSICDCL 1340 LATLANSESS 1350 YNCLLTCVRT 1360 MMFLAEHDYG 1370 LFHLKSSLRK 1380 NSSALHSLLK 1390 RVVSTFSKDT 1400 GELASSFLEF 1410 MRQILNSDTI 1420 GCCGDDNGLM 1430 EVEGAHTSRT 1440 MSINAAELKQ 1450 LLQSKEESPE 1460 NLFLELEKLV 1470 LEHSKDDDNL 1480 DSLLDSVVGL 1490 KQMLESSGDP 1500 LPLSDQDVEP 1510 VLSAPESLQN 1520 LFNNRTAYVL 1530 ADVMDDQLKS 1540 MWFTPFQAEE 1550 IDTDLDLVKV 1560 DLIELSEKCC 1570 SDFDLHSELE 1580 RSFLSEPSSP 1590 GRTKTTKGFK 1600 LGKHKHETFI 1610 TSSGKSEYIE 1620 PAKRAHVVPP 1630 PRGRGRGGFG 1640 QGIRPHDIFR 1650 QRKQNTSRPP 1660 SMHVDDFVAA 1670 ESKEVVPQDG 1680 IPPPKRPLKV 1690 SQKISSRGGF 1700 SGNRGGRGAF 1710 HSQNRFFTPP 1720 ASKGNYSRRE 1730 GTRGSSWSAQ 1740 NTPRGNYNES 1750 RGGQSNFNRG 1760 PLPPLRPLSS 1770 TGYRPSPRDR 1780 ASRGRGGLGP 1790 SWASANSGSG 1800 GSRGKFVSGG 1810 SGRGRHVRSF TR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0008380	RNA splicing

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.