Overview
| Uniprot ID | Q6DD88 |
|---|
| Protein Name | Atlastin-3 |
|---|
| Gene Name | ATL3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 239 |
LDKRLQVKEHQHEEI |
| 391 |
EEKHCEFKQLALDHF |
Function
Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:24459106, PubMed:27619977, PubMed:37102997). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)
Protein Sequence
10
MLSPQRVAAA
20
ASRGADDAME
30
SSKPGPVQVV
40
LVQKDQHSFE
50
LDEKALASIL
60
LQDHIRDLDV
70
VVVSVAGAFR
80
KGKSFILDFM
90
LRYLYSQKES
100
GHSNWLGDPE
110
EPLTGFSWRG
120
GSDPETTGIQ
130
IWSEVFTVEK
140
PGGKKVAVVL
150
MDTQGAFDSQ
160
STVKDCATIF
170
ALSTMTSSVQ
180
IYNLSQNIQE
190
DDLQQLQLFT
200
EYGRLAMDEI
210
FQKPFQTLMF
220
LVRDWSFPYE
230
YSYGLQGGMA
240
FLDKRLQVKE
250
HQHEEIQNVR
260
NHIHSCFSDV
270
TCFLLPHPGL
280
QVATSPDFDG
290
KLKDIAGEFK
300
EQLQALIPYV
310
LNPSKLMEKE
320
INGSKVTCRG
330
LLEYFKAYIK
340
IYQGEDLPHP
350
KSMLQATAEA
360
NNLAAAASAK
370
DIYYNNMEEV
380
CGGEKPYLSP
390
DILEEKHCEF
400
KQLALDHFKK
410
TKKMGGKDFS
420
FRYQQELEEE
430
IKELYENFCK
440
HNGSKNVFST
450
FRTPAVLFTG
460
IVALYIASGL
470
TGFIGLEVVA
480
QLFNCMVGLL
490
LIALLTWGYI
500
RYSGQYRELG
510
GAIDFGAAYV
520
LEQASSHIGN
530
STQATVRDAV
540
VGRPSMDKKA
Q
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0071782 |
endoplasmic reticulum tubular network |
| Cellular Component |
GO:0098826 |
endoplasmic reticulum tubular network membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0140523 |
GTPase-dependent fusogenic activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0016320 |
endoplasmic reticulum membrane fusion |
| Biological Process |
GO:0007029 |
endoplasmic reticulum organization |
| Biological Process |
GO:1990809 |
endoplasmic reticulum tubular network membrane organization |
| Biological Process |
GO:0051260 |
protein homooligomerization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.