Search Results
Overview
| Uniprot ID | Q6EEV6 |
|---|---|
| Protein Name | Small ubiquitin-related modifier 4 |
| Gene Name | SUMO4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | DGSVVQFKIKRQTPL |
Function
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I
Protein Sequence
10
MANEKPTEEV
20
KTENNNHINL
30
KVAGQDGSVV
40
QFKIKRQTPL
50
SKLMKAYCEP
60
RGLSVKQIRF
70
RFGGQPISGT
80
DKPAQLEMED
90
EDTIDVFQQP
TGGVY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0106068 | SUMO ligase complex |
| Molecular Function | GO:0031386 | protein tag activity |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0043392 | negative regulation of DNA binding |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0043388 | positive regulation of DNA binding |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:1900180 | regulation of protein localization to nucleus |
Reference
PMID: N/A