Search Results

Overview

Uniprot ID	Q6F5E8
Protein Name	Capping protein, Arp2/3 and myosin-I linker protein 2
Gene Name	CARMIL2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1097	VPRTLRKKLGTLFAF

Function

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205)

Protein Sequence

10 MAQTPDGISC 20 ELRGEITRFL 30 WPKEVELLLK 40 TWLPGEGAVQ 50 NHVLALLRWR 60 AYLLHTTCLP 70 LRVDCTFSYL 80 EVQAMALQET 90 PPQVTFELES 100 LRELVLEFPG 110 VAALEQLAQH 120 VAAAIKKVFP 130 RSTLGKLFRR 140 PTPASMLARL 150 ERSSPSESTD 160 PCSPCGGFLE 170 TYEALCDYNG 180 FPFREEIQWD 190 VDTIYHRQGC 200 RHFSLGDFSH 210 LGSRDLALSV 220 AALSYNLWFR 230 CLSCVDMKLS 240 LEVSEQILHM 250 MSQSSHLEEL 260 VLETCSLRGD 270 FVRRLAQALA 280 GHSSSGLREL 290 SLAGNLLDDR 300 GMTALSRHLE 310 RCPGALRRLS 320 LAQTGLTPRG 330 MRALGRALAT 340 NAAFDSTLTH 350 LDLSGNPGAL 360 GASEDSGGLY 370 SFLSRPNVLS 380 FLNLAGTDTA 390 LDTVRGCSVG 400 GWMTGRADWR 410 AGRGGLGPPA 420 GVANSLPPQL 430 FAAVSRGCCT 440 SLTHLDASRN 450 VFSRTKSRAA 460 PAALQLFLSR 470 ARTLRHLGLA 480 GCKLPPDALR 490 ALLDGLALNT 500 HLRDLHLDLS 510 ACELRSAGAQ 520 VIQDLVCDAG 530 AVSSLDLADN 540 GFGSDMVTLV 550 LAIGRSRSLR 560 HVALGRNFNV 570 RCKETLDDVL 580 HRIVQLMQDD 590 DCPLQSLSVA 600 ESRLKLGASV 610 LLRALATNPN 620 LTALDISGNA 630 MGDAGAKLLA 640 KALRVNSRLR 650 SVVWDRNHTS 660 ALGLLDVAQA 670 LEQNHSLKAM 680 PLPLNDVAQA 690 QRSRPELTAR 700 AVHQIQACLL 710 RNNRADPASS 720 DHTTRLQPLG 730 LVSDPSEQEV 740 NELCQSVQEH 750 VELLGCGAGP 760 QGEAAVRQAE 770 DAIQNANFSL 780 SILPILYEAG 790 SSPSHHWQLG 800 QKLEGLLRQV 810 GEVCRQDIQD 820 FTQATLDTAR 830 SLCPQMLQGS 840 SWREQLEGVL 850 AGSRGLPELL 860 PEQLLQDAFT 870 RLRDMRLSIT 880 GTLAESIVAQ 890 ALAGLSAARD 900 QLVESLAQQA 910 TVTMPPALPA 920 PDGGEPSLLE 930 PGELEGLFFP 940 EEKEEEKEKD 950 DSPPQKWPEL 960 SHGLHLVPFI 970 HSAAEEAEPE 980 PELAAPGEDA 990 EPQAGPSARG 1000 SPSPAAPGPP 1010 AGPLPRMDLP 1020 LAGQPLRHPT 1030 RARPRPRRQH 1040 HHRPPPGGPQ 1050 VPPALPQEGN 1060 GLSARVDEGV 1070 EEFFSKRLIQ 1080 QDRLWAPEED 1090 PATEGGATPV 1100 PRTLRKKLGT 1110 LFAFKKPRST 1120 RGPRTDLETS 1130 PGAAPRTRKT 1140 TFGDLLRPPT 1150 RPSRGEELGG 1160 AEGDTSSPDP 1170 AGRSRPRYTR 1180 DSKAYSMILL 1190 PAEEEATLGA 1200 RPDKRRPLER 1210 GETELAPSFE 1220 QRVQVMLQRI 1230 GVSRGSGGAE 1240 GKRKQSKDGE 1250 IKKAGSDGDI 1260 MDSSTEAPPI 1270 SIKSRTHSVS 1280 ADPSCRPGPG 1290 SQGPESATWK 1300 TLGQQLNAEL 1310 RSRGWGQQDG 1320 PGPPSPGQSP 1330 SPCRTSPSPD 1340 SLGLPEDPCL 1350 GPRNEDGQLR 1360 PRPLSAGRRA 1370 VSVHEDQLQA 1380 PAERPLRLQR 1390 SPVLKRRPKL 1400 EAPPSPSLGS 1410 GLGTEPLPPQ 1420 PTEPSSPERS 1430 PPSPATDQRG GGPNP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
Cellular Component	GO:0045111	intermediate filament cytoskeleton
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0044354	macropinosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Molecular Function	GO:0005543	phospholipid binding
Molecular Function	GO:0044877	protein-containing complex binding
Biological Process	GO:0051639	actin filament network formation
Biological Process	GO:0016477	cell migration
Biological Process	GO:0007163	establishment or maintenance of cell polarity
Biological Process	GO:0061339	establishment or maintenance of monopolar cell polarity
Biological Process	GO:2000813	negative regulation of barbed-end actin filament capping
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly
Biological Process	GO:0010592	positive regulation of lamellipodium assembly
Biological Process	GO:1902745	positive regulation of lamellipodium organization
Biological Process	GO:1900029	positive regulation of ruffle assembly
Biological Process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
Biological Process	GO:0044319	wound healing, spreading of cells
Cellular Component	GO:0031252	cell leading edge

Reference

PMID: N/A