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Overview

Uniprot ID	Q6FIF0
Protein Name	AN1-type zinc finger protein 6
Gene Name	ZFAND6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
195	DAAEKIRKENPVVVG

Function

Involved in regulation of TNF induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)

Protein Sequence

10 MAQETNHSQV 20 PMLCSTGCGF 30 YGNPRTNGMC 40 SVCYKEHLQR 50 QNSSNGRISP 60 PATSVSSLSE 70 SLPVQCTDGS 80 VPEAQSALDS 90 TSSSMQPSPV 100 SNQSLLSESV 110 ASSQLDSTSV 120 DKAVPETEDV 130 QASVSDTAQQ 140 PSEEQSKSLE 150 KPKQKKNRCF 160 MCRKKVGLTG 170 FECRCGNVYC 180 GVHRYSDVHN 190 CSYNYKADAA 200 EKIRKENPVV VGEKIQKI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0006625	protein targeting to peroxisome
Biological Process	GO:0015031	protein transport
Biological Process	GO:0043122	regulation of canonical NF-kappaB signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.