Overview
| Uniprot ID | Q6I9Y2 |
|---|
| Protein Name | THO complex subunit 7 |
|---|
| Gene Name | THOC7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 114 |
LQAKRIRKNRQEYDA |
Function
Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602)
Protein Sequence
10
MGAVTDDEVI
20
RKRLLIDGDG
30
AGDDRRINLL
40
VKSFIKWCNS
50
GSQEEGYSQY
60
QRMLSTLSQC
70
EFSMGKTLLV
80
YDMNLREMEN
90
YEKIYKEIEC
100
SIAGAHEKIA
110
ECKKQILQAK
120
RIRKNRQEYD
130
ALAKVIQHHP
140
DRHETLKELE
150
ALGKELEHLS
160
HIKESVEDKL
170
ELRRKQFHVL
180
LSTIHELQQT
190
LENDEKLSEV
200
EEAQEASMET
DPKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000347 |
THO complex |
| Cellular Component |
GO:0000445 |
THO complex part of transcription export complex |
| Cellular Component |
GO:0000346 |
transcription export complex |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
PMID: N/A