Search Results

Overview

Uniprot IDQ6IB77
Protein NameGlycine N-acyltransferase
Gene NameGLYAT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 QMLQMLEKSLRKSLP
161 SPNGGKPKAINQEMF
169 AINQEMFKLSSMDVT
183 THAHLVNKFWHFGGN
20 MLEKSLRKSLPASLK
253 VIYSHAQKLGKLGFP
256 SHAQKLGKLGFPVYS

Function

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid

Protein Sequence

10 MMLPLQGAQM 20 LQMLEKSLRK 30 SLPASLKVYG 40 TVFHINHGNP 50 FNLKAVVDKW 60 PDFNTVVVCP 70 QEQDMTDDLD 80 HYTNTYQIYS 90 KDPQNCQEFL 100 GSPELINWKQ 110 HLQIQSSQPS 120 LNEAIQNLAA 130 IKSFKVKQTQ 140 RILYMAAETA 150 KELTPFLLKS 160 KILSPNGGKP 170 KAINQEMFKL 180 SSMDVTHAHL 190 VNKFWHFGGN 200 ERSQRFIERC 210 IQTFPTCCLL 220 GPEGTPVCWD 230 LMDQTGEMRM 240 AGTLPEYRLH 250 GLVTYVIYSH 260 AQKLGKLGFP 270 VYSHVDYSNE 280 AMQKMSYTLQ 290 HVPIPRSWNQ WNCVPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0016746 acyltransferase activity
Molecular Function GO:0047961 glycine N-acyltransferase activity
Molecular Function GO:0047962 glycine N-benzoyltransferase activity
Biological Process GO:0006637 acyl-CoA metabolic process
Biological Process GO:1901787 benzoyl-CoA metabolic process
Biological Process GO:0006544 glycine metabolic process
Biological Process GO:0032787 monocarboxylic acid metabolic process
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.