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Overview

Uniprot IDQ6IBM8
Protein Name116 kDa U5 small nuclear ribonucleoprotein component
Gene NameU5-116KD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
561 GVDQPIVKTATITEP

Function

Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs

Protein Sequence

10 MDTDLYDEFG 20 NYIGPELDSD 30 EDDDELGRET 40 KDLDEMDDDD 50 DDDDVGDHDD 60 DHPGMEVVLH 70 EDKKYYPTAE 80 EVYGPEVETI 90 VQEEDTQPLT 100 EPIIKPVKTK 110 KFTLMEQTLP 120 VTVYEMDFLA 130 DLMDNSELIR 140 NVTLCGHLHH 150 GKTCFVDCLI 160 EQTHPEIRKR 170 YDQDLCYTDI 180 LFTEQERGVG 190 IKSTPVTVVL 200 PDTKGKSYLF 210 NIMDTPGHVN 220 FSDEVTAGLR 230 ISDGVVLFID 240 AAEGVMLNTE 250 RLIKHAVQER 260 LAVTVCINKI 270 DRLILELKLP 280 PTDAYYKLRH 290 IVDEVNGLIS 300 MYSTDENLIL 310 SPLLGNVCFS 320 SSQYSICFTL 330 VSFAKIYADT 340 FGDINYQEFA 350 KRLWGDIYFN 360 PKTRKFTKKA 370 PTSSSQRSFV 380 EFILEPLYKI 390 LAQVVGDVDT 400 SLPRTLDELG 410 IHLTKEELKL 420 NIRPLLRLVC 430 KKFFGEFTGF 440 VDMCVQHIPS 450 PKVGAKPKIE 460 HTYTGGVDSD 470 LGEAMSDCDP 480 DGPLMCHTTK 490 MYSTDDGVQF 500 HAFGRVLSGT 510 IHAGQPVKVL 520 GENYTLEDEE 530 DSQICTVGRL 540 WISVARYHIE 550 VNRVPAGNWV 560 LIEGVDQPIV 570 KTATITEPRG 580 NEEAQIFRPL 590 KFNTTSVIKI 600 AVEPVNPSEL 610 PKMLDGLRKV 620 NKSYPSLTTK 630 VEESGEHVIL 640 GTGELYLDCV 650 MHDLRKMYSE 660 IDIKVADPVV 670 TFCETVVETS 680 SLKCFAETPN 690 KKNKITMIAE 700 PLEKGLAEDI 710 ENEVVQITWN 720 RKKLGEFFQT 730 KYDWDLLAAR 740 SIWAFGPDAT 750 GPNILVDDTL 760 PSEVDKALLG 770 SVKDSIVQGF 780 QWGTREGPLC 790 DELIRNVKFK 800 ILDAVVAQEP 810 LHRGGGQIIP 820 TARRVVYSAF 830 LMATPRLMEP 840 YYFVEVQAPA 850 DCVSAVYTVL 860 ARRRGHVTQD 870 APIPGSPLYT 880 IKAFIPAIDS 890 FGFETDLRTH 900 TQGQAFSLSV 910 FHHWQIVPGD 920 PLDKSIVIRP 930 LEPQPAPHLA 940 REFMIKTRRR 950 KGLSEDVSIS 960 KFFDDPMLLE 970 LAKQDVVLNY PI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

PMID: N/A