Search Results

Overview

Uniprot IDQ6IBS0
Protein NameTwinfilin-2
Gene NameTWF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
171 TEISVESKHQTLQGL
194 QRALQQLKQKMVNYI
320 HPKQHAFKQAFAKPK
325 AFKQAFAKPKGPGGK
327 KQAFAKPKGPGGKRG

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity)

Protein Sequence

10 MAHQTGIHAT 20 EELKEFFAKA 30 RAGSVRLIKV 40 VIEDEQLVLG 50 ASQEPVGRWD 60 QDYDRAVLPL 70 LDAQQPCYLL 80 YRLDSQNAQG 90 FEWLFLAWSP 100 DNSPVRLKML 110 YAATRATVKK 120 EFGGGHIKDE 130 LFGTVKDDLS 140 FAGYQKHLSS 150 CAAPAPLTSA 160 ERELQQIRIN 170 EVKTEISVES 180 KHQTLQGLAF 190 PLQPEAQRAL 200 QQLKQKMVNY 210 IQMKLDLERE 220 TIELVHTEPT 230 DVAQLPSRVP 240 RDAARYHFFL 250 YKHTHEGDPL 260 ESVVFIYSMP 270 GYKCSIKERM 280 LYSSCKSRLL 290 DSVEQDFHLE 300 IAKKIEIGDG 310 AELTAEFLYD 320 EVHPKQHAFK 330 QAFAKPKGPG 340 GKRGHKRLIR GPGENGDDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0030175 filopodium
Cellular Component GO:0030426 growth cone
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0030016 myofibril
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032420 stereocilium
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0005080 protein kinase C binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0030030 cell projection organization
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0030837 negative regulation of actin filament polymerization
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:0010592 positive regulation of lamellipodium assembly
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0010591 regulation of lamellipodium assembly
Biological Process GO:0032532 regulation of microvillus length
Cellular Component GO:0005737 cytoplasm

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.