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Overview

Uniprot IDQ6IPR1
Protein NameElectron transfer flavoprotein regulatory factor 1
Gene NameETFRF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
42 RLKNIFLKNKDVKNP

Function

Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB)

Protein Sequence

10 MKMANSLRGE 20 VLKLYKNLLY 30 LGRDYPKGAD 40 YFKKRLKNIF 50 LKNKDVKNPE 60 KIKELIAQGE 70 FVMKELEALY 80 FLRKYRAMKQ 90 RYYSDTNKTN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004857 enzyme inhibitor activity
Biological Process GO:1901856 negative regulation of cellular respiration
Biological Process GO:0090324 negative regulation of oxidative phosphorylation

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.