Search Results
Overview
| Uniprot ID | Q6IPR3 |
|---|---|
| Protein Name | tRNA wybutosine-synthesizing protein 3 homolog |
| Gene Name | TYW3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 219 | NNSSYIHKKKRNPEK |
Function
S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame. Catalyzes the methylation of 4-demethylwyosine, generating intermediates required for the formation of mature wybutosine
Protein Sequence
10
MDRSAEFRKW
20
KAQCLSKADL
30
SRKGSVDEDV
40
VELVQFLNMR
50
DQFFTTSSCA
60
GRILLLDRGI
70
NGFEVQKQNC
80
CWLLVTHKLC
90
VKDDVIVALK
100
KANGDATLKF
110
EPFVLHVQCR
120
QLQDAQILHS
130
MAIDSGFRNS
140
GITVGKRGKT
150
MLAVRSTHGL
160
EVPLSHKGKL
170
MVTEEYIDFL
180
LNVANQKMEE
190
NKKRIERFYN
200
CLQHALERET
210
MTNLHPKIKE
220
KNNSSYIHKK
230
KRNPEKTRAQ
240
CITKESDEEL
250
ENDDDDDLGI
NVTIFPEDY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0008175 | tRNA methyltransferase activity |
| Biological Process | GO:0030488 | tRNA methylation |
| Biological Process | GO:0031591 | wybutosine biosynthetic process |
Reference
PMID: N/A