Search Results
Overview
| Uniprot ID | Q6IQ26 |
|---|---|
| Protein Name | DENN domain-containing protein 5A |
| Gene Name | DENND5A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 645 | AIELRLAKIDHTAIH |
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity)
Protein Sequence
10
MSGGGGGGGS
20
APSRFADYFV
30
ICGLDTETGL
40
EPDELSALCQ
50
YIQASKARDG
60
ASPFISSTTE
70
GENFEQTPLR
80
RTFKSKVLAR
90
YPENVEWNPF
100
DQDAVGMLCM
110
PKGLAFKTQA
120
DPREPQFHAF
130
IITREDGSRT
140
FGFALTFYEE
150
VTSKQICSAM
160
QTLYHMHNAE
170
YDVLHAPPAD
180
DRDQSSMEDG
190
EDTPVTKLQR
200
FNSYDISRDT
210
LYVSKCICLI
220
TPMSFMKACR
230
SVLEQLHQAV
240
TSPQPPPLPL
250
ESYIYNVLYE
260
VPLPPPGRSL
270
KFSGVYGPII
280
CQRPSTNELP
290
LFDFPVKEVF
300
ELLGVENVFQ
310
LFTCALLEFQ
320
ILLYSQHYQR
330
LMTVAETITA
340
LMFPFQWQHV
350
YVPILPASLL
360
HFLDAPVPYL
370
MGLHSNGLDD
380
RSKLELPQEA
390
NLCFVDIDNH
400
FIELPEDLPQ
410
FPNKLEFVQE
420
VSEILMAFGI
430
PPEGNLHCSE
440
SASKLKRLRA
450
SELVSDKRNG
460
NIAGSPLHSY
470
ELLKENETIA
480
RLQALVKRTG
490
VSLEKLEVRE
500
DPSSNKDLKV
510
QCDEEELRIY
520
QLNIQIREVF
530
ANRFTQMFAD
540
YEVFVIQPSQ
550
DKESWFTNRE
560
QMQNFDKASF
570
LSDQPEPYLP
580
FLSRFLETQM
590
FASFIDNKIM
600
CHDDDDKDPV
610
LRVFDSRVDK
620
IRLLNVRTPT
630
LRTSMYQKCT
640
TVDEAEKAIE
650
LRLAKIDHTA
660
IHPHLLDMKI
670
GQGKYEPGFF
680
PKLQSDVLST
690
GPASNKWTKR
700
NAPAQWRRKD
710
RQKQHTEHLR
720
LDNDQREKYI
730
QEARTMGSTI
740
RQPKLSNLSP
750
SVIAQTNWKF
760
VEGLLKECRN
770
KTKRMLVEKM
780
GREAVELGHG
790
EVNITGVEEN
800
TLIASLCDLL
810
ERIWSHGLQV
820
KQGKSALWSH
830
LLHYQDNRQR
840
KLTSGSLSTS
850
GILLDSERRK
860
SDASSLMPPL
870
RISLIQDMRH
880
IQNIGEIKTD
890
VGKARAWVRL
900
SMEKKLLSRH
910
LKQLLSDHEL
920
TKKLYKRYAF
930
LRCDDEKEQF
940
LYHLLSFNAV
950
DYFCFTNVFT
960
TILIPYHILI
970
VPSKKLGGSM
980
FTANPWICIS
990
GELGETQIMQ
1000
IPRNVLEMTF
1010
ECQNLGKLTT
1020
VQIGHDNSGL
1030
YAKWLVEYVM
1040
VRNEITGHTY
1050
KFPCGRWLGK
1060
GMDDGSLERI
1070
LVGELLTSQP
1080
EVDERPCRTP
1090
PLQQSPSVIR
1100
RLVTISPNNK
1110
PKLNTGQIQE
1120
SIGEAVNGIV
1130
KHFHKPEKER
1140
GSLTLLLCGE
1150
CGLVSALEQA
1160
FQHGFKSPRL
1170
FKNVFIWDFL
1180
EKAQTYYETL
1190
EKNEVVPEEN
1200
WHTRARNFCR
1210
FVTAINNTPR
1220
NIGKDGKFQM
1230
LVCLGARDHL
1240
LHHWIALLAD
1250
CPITAHMYED
1260
VALIKDHTLV
1270
NSLIRVLQTL
1280
QEFNITLETS
LVKGIDI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.