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Overview

Uniprot IDQ6IQ26
Protein NameDENN domain-containing protein 5A
Gene NameDENND5A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
645 AIELRLAKIDHTAIH

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity)

Protein Sequence

10 MSGGGGGGGS 20 APSRFADYFV 30 ICGLDTETGL 40 EPDELSALCQ 50 YIQASKARDG 60 ASPFISSTTE 70 GENFEQTPLR 80 RTFKSKVLAR 90 YPENVEWNPF 100 DQDAVGMLCM 110 PKGLAFKTQA 120 DPREPQFHAF 130 IITREDGSRT 140 FGFALTFYEE 150 VTSKQICSAM 160 QTLYHMHNAE 170 YDVLHAPPAD 180 DRDQSSMEDG 190 EDTPVTKLQR 200 FNSYDISRDT 210 LYVSKCICLI 220 TPMSFMKACR 230 SVLEQLHQAV 240 TSPQPPPLPL 250 ESYIYNVLYE 260 VPLPPPGRSL 270 KFSGVYGPII 280 CQRPSTNELP 290 LFDFPVKEVF 300 ELLGVENVFQ 310 LFTCALLEFQ 320 ILLYSQHYQR 330 LMTVAETITA 340 LMFPFQWQHV 350 YVPILPASLL 360 HFLDAPVPYL 370 MGLHSNGLDD 380 RSKLELPQEA 390 NLCFVDIDNH 400 FIELPEDLPQ 410 FPNKLEFVQE 420 VSEILMAFGI 430 PPEGNLHCSE 440 SASKLKRLRA 450 SELVSDKRNG 460 NIAGSPLHSY 470 ELLKENETIA 480 RLQALVKRTG 490 VSLEKLEVRE 500 DPSSNKDLKV 510 QCDEEELRIY 520 QLNIQIREVF 530 ANRFTQMFAD 540 YEVFVIQPSQ 550 DKESWFTNRE 560 QMQNFDKASF 570 LSDQPEPYLP 580 FLSRFLETQM 590 FASFIDNKIM 600 CHDDDDKDPV 610 LRVFDSRVDK 620 IRLLNVRTPT 630 LRTSMYQKCT 640 TVDEAEKAIE 650 LRLAKIDHTA 660 IHPHLLDMKI 670 GQGKYEPGFF 680 PKLQSDVLST 690 GPASNKWTKR 700 NAPAQWRRKD 710 RQKQHTEHLR 720 LDNDQREKYI 730 QEARTMGSTI 740 RQPKLSNLSP 750 SVIAQTNWKF 760 VEGLLKECRN 770 KTKRMLVEKM 780 GREAVELGHG 790 EVNITGVEEN 800 TLIASLCDLL 810 ERIWSHGLQV 820 KQGKSALWSH 830 LLHYQDNRQR 840 KLTSGSLSTS 850 GILLDSERRK 860 SDASSLMPPL 870 RISLIQDMRH 880 IQNIGEIKTD 890 VGKARAWVRL 900 SMEKKLLSRH 910 LKQLLSDHEL 920 TKKLYKRYAF 930 LRCDDEKEQF 940 LYHLLSFNAV 950 DYFCFTNVFT 960 TILIPYHILI 970 VPSKKLGGSM 980 FTANPWICIS 990 GELGETQIMQ 1000 IPRNVLEMTF 1010 ECQNLGKLTT 1020 VQIGHDNSGL 1030 YAKWLVEYVM 1040 VRNEITGHTY 1050 KFPCGRWLGK 1060 GMDDGSLERI 1070 LVGELLTSQP 1080 EVDERPCRTP 1090 PLQQSPSVIR 1100 RLVTISPNNK 1110 PKLNTGQIQE 1120 SIGEAVNGIV 1130 KHFHKPEKER 1140 GSLTLLLCGE 1150 CGLVSALEQA 1160 FQHGFKSPRL 1170 FKNVFIWDFL 1180 EKAQTYYETL 1190 EKNEVVPEEN 1200 WHTRARNFCR 1210 FVTAINNTPR 1220 NIGKDGKFQM 1230 LVCLGARDHL 1240 LHHWIALLAD 1250 CPITAHMYED 1260 VALIKDHTLV 1270 NSLIRVLQTL 1280 QEFNITLETS LVKGIDI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.