Search Results
Overview
| Uniprot ID | Q6IQ49 |
|---|---|
| Protein Name | Splicing regulator SDE2 |
| Gene Name | SDE2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 261 | NGVEMAAKFPSGSQR |
| 447 | ALFAKPLKGKKK*** |
| 449 | FAKPLKGKKK***** |
| 94 | ALGAQIEKTTNREAC |
Function
Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959)
Protein Sequence
10
MAEAAALVWI
20
RGPGFGCKAV
30
RCASGRCTVR
40
DFIHRHCQDQ
50
NVPVENFFVK
60
CNGALINTSD
70
TVQHGAVYSL
80
EPRLCGGKGG
90
FGSMLRALGA
100
QIEKTTNREA
110
CRDLSGRRLR
120
DVNHEKAMAE
130
WVKQQAEREA
140
EKEQKRLERL
150
QRKLVEPKHC
160
FTSPDYQQQC
170
HEMAERLEDS
180
VLKGMQAASS
190
KMVSAEISEN
200
RKRQWPTKSQ
210
TDRGASAGKR
220
RCFWLGMEGL
230
ETAEGSNSES
240
SDDDSEEAPS
250
TSGMGFHAPK
260
IGSNGVEMAA
270
KFPSGSQRAR
280
VVNTDHGSPE
290
QLQIPVTDSG
300
RHILEDSCAE
310
LGESKEHMES
320
RMVTETEETQ
330
EKKAESKEPI
340
EEEPTGAGLN
350
KDKETEERTD
360
GERVAEVAPE
370
ERENVAVAKL
380
QESQPGNAVI
390
DKETIDLLAF
400
TSVAELELLG
410
LEKLKCELMA
420
LGLKCGGTLQ
430
ERAARLFSVR
440
GLAKEQIDPA
450
LFAKPLKGKK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0030515 | snoRNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0031571 | mitotic G1 DNA damage checkpoint signaling |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0016485 | protein processing |
| Biological Process | GO:0016567 | protein ubiquitination |
Reference
PMID: N/A