Search Results

Overview

Uniprot IDQ6KC79
Protein NameNipped-B-like protein
Gene NameNIPBL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1032 RSSLKPIKNKPSKSN
1040 NKPSKSNKGSIDQSV
1369 GGGLLSSKAKRAKCS
1599 LVHQFSNKSTEMALR
222 LRNIHDNKVSGPLSG
2574 YSPSESAKVYDKAIN
289 AGSEGTPKGSRPPLI
333 QKKMKLGKDEKEQSE
353 DIISSPSKDSTKLTL
357 SPSKDSTKLTLRLSR
493 IERERFSKEVQDKDK
504 DKDKPLKKRKQDSYP
506 DKPLKKRKQDSYPQE
603 HPETPKKKSDPELSK
610 KSDPELSKSEMKQSE
634 ENRLVETKSSENKLE
639 ETKSSENKLETKVET
697 NGRSETTKSRPETPK
726 DGHPETPKQKGDGRP
759 EGRPETPKHRHDNRR
787 SKHKQDTKSDSPRLK
802 SERAEALKQRPDGRS
857 SRNEHGIKSDSSKTD
862 GIKSDSSKTDKLERK
865 SDSSKTDKLERKHRH
907 SNKSRSDKLGFKSPT
911 RSDKLGFKSPTSKDD
916 GFKSPTSKDDKRTEG
932 KSKVDTNKAHPDNKA
954 GGRSGALKNFVIPKI
960 LKNFVIPKIKRDKDG
962 NFVIPKIKRDKDGNV
965 IPKIKRDKDGNVTQE

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity)

Protein Sequence

10 MNGDMPHVPI 20 TTLAGIASLT 30 DLLNQLPLPS 40 PLPATTTKSL 50 LFNARIAEEV 60 NCLLACRDDN 70 LVSQLVHSLN 80 QVSTDHIELK 90 DNLGSDDPEG 100 DIPVLLQAVL 110 ARSPNVFREK 120 SMQNRYVQSG 130 MMMSQYKLSQ 140 NSMHSSPASS 150 NYQQTTISHS 160 PSSRFVPPQT 170 SSGNRFMPQQ 180 NSPVPSPYAP 190 QSPAGYMPYS 200 HPSSYTTHPQ 210 MQQASVSSPI 220 VAGGLRNIHD 230 NKVSGPLSGN 240 SANHHADNPR 250 HGSSEDYLHM 260 VHRLSSDDGD 270 SSTMRNAASF 280 PLRSPQPVCS 290 PAGSEGTPKG 300 SRPPLILQSQ 310 SLPCSSPRDV 320 PPDILLDSPE 330 RKQKKQKKMK 340 LGKDEKEQSE 350 KAAMYDIISS 360 PSKDSTKLTL 370 RLSRVRSSDM 380 DQQEDMISGV 390 ENSNVSENDI 400 PFNVQYPGQT 410 SKTPITPQDI 420 NRPLNAAQCL 430 SQQEQTAFLP 440 ANQVPVLQQN 450 TSVAAKQPQT 460 SVVQNQQQIS 470 QQGPIYDEVE 480 LDALAEIERI 490 ERESAIERER 500 FSKEVQDKDK 510 PLKKRKQDSY 520 PQEAGGATGG 530 NRPASQETGS 540 TGNGSRPALM 550 VSIDLHQAGR 560 VDSQASITQD 570 SDSIKKPEEI 580 KQCNDAPVSV 590 LQEDIVGSLK 600 STPENHPETP 610 KKKSDPELSK 620 SEMKQSESRL 630 AESKPNENRL 640 VETKSSENKL 650 ETKVETQTEE 660 LKQNESRTTE 670 CKQNESTIVE 680 PKQNENRLSD 690 TKPNDNKQNN 700 GRSETTKSRP 710 ETPKQKGESR 720 PETPKQKSDG 730 HPETPKQKGD 740 GRPETPKQKG 750 ESRPETPKQK 760 NEGRPETPKH 770 RHDNRRDSGK 780 PSTEKKPEVS 790 KHKQDTKSDS 800 PRLKSERAEA 810 LKQRPDGRSV 820 SESLRRDHDN 830 KQKSDDRGES 840 ERHRGDQSRV 850 RRPETLRSSS 860 RNEHGIKSDS 870 SKTDKLERKH 880 RHESGDSRER 890 PSSGEQKSRP 900 DSPRVKQGDS 910 NKSRSDKLGF 920 KSPTSKDDKR 930 TEGNKSKVDT 940 NKAHPDNKAE 950 FPSYLLGGRS 960 GALKNFVIPK 970 IKRDKDGNVT 980 QETKKMEMKG 990 EPKDKVEKIG 1000 LVEDLNKGAK 1010 PVVVLQKLSL 1020 DDVQKLIKDR 1030 EDKSRSSLKP 1040 IKNKPSKSNK 1050 GSIDQSVLKE 1060 LPPELLAEIE 1070 STMPLCERVK 1080 MNKRKRSTVN 1090 EKPKYAEISS 1100 DEDNDSDEAF 1110 ESSRKRHKKD 1120 DDKAWEYEER 1130 DRRSSGDHRR 1140 SGHSHEGRRS 1150 SGGGRYRNRS 1160 PSDSDMEDYS 1170 PPPSLSEVAR 1180 KMKKKEKQKK 1190 RKAYEPKLTP 1200 EEMMDSSTFK 1210 RFTASIENIL 1220 DNLEDMDFTA 1230 FGDDDEIPQE 1240 LLLGKHQLNE 1250 LGSESAKIKA 1260 MGIMDKLSTD 1270 KTVKVLNILE 1280 KNIQDGSKLS 1290 TLLNHNNDTE 1300 EEERLWRDLI 1310 MERVTKSADA 1320 CLTTINIMTS 1330 PNMPKAVYIE 1340 DVIERVIQYT 1350 KFHLQNTLYP 1360 QYDPVYRLDP 1370 HGGGLLSSKA 1380 KRAKCSTHKQ 1390 RVIVMLYNKV 1400 CDIVSSLSEL 1410 LEIQLLTDTT 1420 ILQVSSMGIT 1430 PFFVENVSEL 1440 QLCAIKLVTA 1450 VFSRYEKHRQ 1460 LILEEIFTSL 1470 ARLPTSKRSL 1480 RNFRLNSSDM 1490 DGEPMYIQMV 1500 TALVLQLIQC 1510 VVHLPSSEKD 1520 SNAEEDSNKK 1530 IDQDVVITNS 1540 YETAMRTAQN 1550 FLSIFLKKCG 1560 SKQGEEDYRP 1570 LFENFVQDLL 1580 STVNKPEWPA 1590 AELLLSLLGR 1600 LLVHQFSNKS 1610 TEMALRVASL 1620 DYLGTVAARL 1630 RKDAVTSKMD 1640 QGSIERILKQ 1650 VSGGEDEIQQ 1660 LQKALLDYLD 1670 ENTETDPSLV 1680 FSRKFYIAQW 1690 FRDTTLETEK 1700 AMKSQKDEES 1710 SEGTHHAKEI 1720 ETTGQIMHRA 1730 ENRKKFLRSI 1740 IKTTPSQFST 1750 LKMNSDTVDY 1760 DDACLIVRYL 1770 ASMRPFAQSF 1780 DIYLTQILRV 1790 LGENAIAVRT 1800 KAMKCLSEVV 1810 AVDPSILARL 1820 DMQRGVHGRL 1830 MDNSTSVREA 1840 AVELLGRFVL 1850 CRPQLAEQYY 1860 DMLIERILDT 1870 GISVRKRVIK 1880 ILRDICIEQP 1890 TFPKITEMCV 1900 KMIRRVNDEE 1910 GIKKLVNETF 1920 QKLWFTPTPH 1930 NDKEAMTRKI 1940 LNITDVVAAC 1950 RDTGYDWFEQ 1960 LLQNLLKSEE 1970 DSSYKPVKKA 1980 CTQLVDNLVE 1990 HILKYEESLA 2000 DSDNKGVNSG 2010 RLVACITTLF 2020 LFSKIRPQLM 2030 VKHAMTMQPY 2040 LTTKCSTQND 2050 FMVICNVAKI 2060 LELVVPLMEH 2070 PSETFLATIE 2080 EDLMKLIIKY 2090 GMTVVQHCVS 2100 CLGAVVNKVT 2110 QNFKFVWACF 2120 NRYYGAISKL 2130 KSQHQEDPNN 2140 TSLLTNKPAL 2150 LRSLFTVGAL 2160 CRHFDFDLED 2170 FKGNSKVNIK 2180 DKVLELLMYF 2190 TKHSDEEVQT 2200 KAIIGLGFAF 2210 IQHPSLMFEQ 2220 EVKNLYNNIL 2230 SDKNSSVNLK 2240 IQVLKNLQTY 2250 LQEEDTRMQQ 2260 ADRDWKKVAK 2270 QEDLKEMGDV 2280 SSGMSSSIMQ 2290 LYLKQVLEAF 2300 FHTQSSVRHF 2310 ALNVIALTLN 2320 QGLIHPVQCV 2330 PYLIAMGTDP 2340 EPAMRNKADQ 2350 QLVEIDKKYA 2360 GFIHMKAVAG 2370 MKMSYQVQQA 2380 INTCLKDPVR 2390 GFRQDESSSA 2400 LCSHLYSMIR 2410 GNRQHRRAFL 2420 ISLLNLFDDT 2430 AKTDVTMLLY 2440 IADNLACFPY 2450 QTQEEPLFIM 2460 HHIDITLSVS 2470 GSNLLQSFKE 2480 SMVKDKRKER 2490 KSSPSKENES 2500 SDSEEEVSRP 2510 RKSRKRVDSD 2520 SDSDSEDDIN 2530 SVMKCLPENS 2540 APLIEFANVS 2550 QGILLLLMLK 2560 QHLKNLCGFS 2570 DSKIQKYSPS 2580 ESAKVYDKAI 2590 NRKTGVHFHP 2600 KQTLDFLRSD 2610 MANSKITEEV 2620 KRSIVKQYLD 2630 FKLLMEHLDP 2640 DEEEEEGEVS 2650 ASTNARNKAI 2660 TSLLGGGSPK 2670 NNTAAETEDD 2680 ESDGEDRGGG 2690 TSGSLRRSKR 2700 NSDSTELAAQ 2710 MNESVDVMDV 2720 IAICCPKYKD 2730 RPQIARVVQK 2740 TSSGFSVQWM 2750 AGSYSGSWTE 2760 AKRRDGRKLV 2770 PWVDTIKESD 2780 IIYKKIALTS 2790 ANKLTNKVVQ 2800 TLRSLYAAKD GTSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0032116 SMC loading complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0061775 cohesin loader activity
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0036033 mediator complex binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0007420 brain development
Biological Process GO:0071481 cellular response to X-ray
Biological Process GO:0140588 chromatin looping
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0050890 cognition
Biological Process GO:0048589 developmental growth
Biological Process GO:0048565 digestive tract development
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042471 ear morphogenesis
Biological Process GO:0048557 embryonic digestive tract morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0034087 establishment of mitotic sister chromatid cohesion
Biological Process GO:0071169 establishment of protein localization to chromatin
Biological Process GO:0035261 external genitalia morphogenesis
Biological Process GO:0048592 eye morphogenesis
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0035136 forelimb morphogenesis
Biological Process GO:0061010 gallbladder development
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0034088 maintenance of mitotic sister chromatid cohesion
Biological Process GO:0001656 metanephros development
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:2001224 positive regulation of neuron migration
Biological Process GO:0048638 regulation of developmental growth
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0042634 regulation of hair cycle
Biological Process GO:1990414 replication-born double-strand break repair via sister chromatid exchange
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0061038 uterus morphogenesis
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0032039 integrator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090694 Scc2-Scc4 cohesin loading complex

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.