Search Results

Overview

Uniprot IDQ6MZM0
Protein NameFerroxidase HEPHL1
Gene NameHEPHL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
342 MIAENPGKWMITCQV

Function

Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species (PubMed:31125343). May be involved in the regulation of intracellular iron content (PubMed:31125343)

Protein Sequence

10 MPRKQPAGCI 20 FLLTFLGLSG 30 LVGTVTRTYY 40 IGIVEEYWNY 50 VPQGKNVITG 60 KSFTEDKLAT 70 LFLERGPNRI 80 GSIYKKAVYR 90 RFTDGTYSIE 100 IPKPPWLGFL 110 GPILRAEVGD 120 VIVIHLKNFA 130 SRPYSLHPHG 140 VFYNKDSEGA 150 LYPDGTSGRN 160 KNDDMVPPGK 170 NYTYVWPVRE 180 EYAPTPADAN 190 CLTWVYHSHI 200 DAPKDICSGL 210 IGPLLVCKEG 220 ILNRYSGTRN 230 DVDREFVIMF 240 TLVDENQSWY 250 LNENIKHFCT 260 NPDSVDKKDA 270 VFQRSNKMHA 280 LNGYLFGNFP 290 EPDMCVGESV 300 SWHLFGMGNE 310 IDIHSIYFYG 320 NTFISRGHRT 330 DVVNLFPATF 340 LTTEMIAENP 350 GKWMITCQVS 360 DHLQAGMLGQ 370 YNVDNCKSDI 380 FYPKMKGQQR 390 RYFIAAEKIL 400 WDYAPQGYNK 410 FSGLPLNASG 420 SDSDLYFTQG 430 DNRIGGKYWK 440 VRYTEFVDAT 450 FTKRKRLSAE 460 EAHLGILGPV 470 IKAEVGDTLL 480 VTFANKADKV 490 YSILPHGVIY 500 DKASDAAPNL 510 DGFVKPGAHV 520 KPGETFTYKW 530 TVPESVSPTA 540 GDPPCLTYLY 550 FSAVDPIKDT 560 SSGLVGPLLV 570 CKKGVLNADG 580 TQKGIDKEFY 590 LLFTVFDENL 600 SRYFDENIQK 610 FIWHPFSIDK 620 EDKEFVKSNR 630 MHAVNGYMYG 640 NQPGLNMCKR 650 DRVSWHLIGL 660 GTDTDMHGIV 670 FQGNTIHLRG 680 THRDSLALFP 690 HMATTAFMQP 700 DHAGIFRVFC 710 ATMPHLSRGM 720 GQIYEVSSCD 730 NRDPSEQRYG 740 MIRTFYIAAE 750 EVEWDYAPNK 760 NWEFEKQHVD 770 ARGERHGDIF 780 MNRTENWIGS 790 QYKKVVYREY 800 TDGEFVEIKA 810 RPPREEHLEL 820 LGPMIHAEVG 830 NTVLIIFKNK 840 ASRPYSISAQ 850 GVEEMDSGKQ 860 FQVPMTKPGE 870 VKTYRWNIPK 880 RSGPGPSDPN 890 CIPWVYYSTV 900 NFVKDTYSGL 910 MGPLITCRKG 920 VLNEKGRRSD 930 VDYEFALLFL 940 VFNENESWYL 950 DDNIKKYLNK 960 DPRDFKRTDD 970 FEESNRMHAI 980 NGKIFGNLHG 990 LIMNEDTMTN 1000 WYLLGIGSEV 1010 DIHTIHYHAE 1020 SFLFKIDKSY 1030 REDVYDLFPG 1040 TFQTIELFAD 1050 HPGTWLLHCH 1060 VSDHIHAGME 1070 TTYTVLRNID 1080 NRIPYSTTSP 1090 GVASHPATVP 1100 SNERPGKEQL 1110 YFFGKNLGPT 1120 GAKAALVILF 1130 IIGLLLLITT 1140 VILSLRLCSA 1150 MKQTDYQQVQ SCALPTDAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005507 copper ion binding
Molecular Function GO:0004322 ferroxidase activity
Biological Process GO:0006825 copper ion transport
Biological Process GO:0006879 intracellular iron ion homeostasis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.