Overview
| Uniprot ID | Q6MZP7 |
|---|
| Protein Name | Protein lin-54 homolog |
|---|
| Gene Name | LIN54 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 249 |
ITKLIFAKPINSKAV |
Function
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258)
Protein Sequence
10
MEVVPAEVNS
20
LLPEEIMDTG
30
ITLVDDDSIE
40
AVIVSSPIPM
50
ETELEEIVNI
60
NSTGDSTATP
70
ISTEPITVYS
80
NHTNQVAVNT
90
TITKADSNTT
100
VKPAFPSGLQ
110
KLGAQTPVTI
120
SANQIILNKV
130
SQTSDLKLGN
140
QTLKPDGQKL
150
ILTTLGKSGS
160
PIVLALPHSQ
170
LPQAQKVTTQ
180
AQSGDAKLPP
190
QQIKVVTIGG
200
RPEVKPVIGV
210
SALTPGSQLI
220
NTTTQPSVLQ
230
TQQLKTVQIA
240
KKPRTPTSGP
250
VITKLIFAKP
260
INSKAVTGQT
270
TQVSPPVIAG
280
RVLSQSTPGT
290
PSKTITISES
300
GVIGSTLNST
310
TQTPNKIAIS
320
PLKSPNKAVK
330
STVQTITVGG
340
VSTSQFKTII
350
PLATAPNVQQ
360
IQVPGSKFHY
370
VRLVTATSAS
380
SSTQPVSQNP
390
STNTQPLQQA
400
KPVVVNTTPV
410
RMSVPIVSAQ
420
AVKQVVPKPI
430
NPTSQIVTTS
440
QPQQRLIMPA
450
TPLPQIQPNL
460
TNLPPGTVLA
470
PAPGTGNVGY
480
AVLPAQYVTQ
490
LQQSSYVSIA
500
SNSTFTGTSG
510
IQTQARLPFN
520
GIIPSESASR
530
PRKPCNCTKS
540
LCLKLYCDCF
550
ANGEFCNNCN
560
CTNCYNNLEH
570
ENERQKAIKA
580
CLDRNPEAFK
590
PKIGKGKEGE
600
SDRRHSKGCN
610
CKRSGCLKNY
620
CECYEAKIMC
630
SSICKCIGCK
640
NFEESPERKT
650
LMHLADAAEV
660
RVQQQTAAKT
670
KLSSQISDLL
680
TRPTPALNSG
690
GGKLPFTFVT
700
KEVAEATCNC
710
LLAQAEQADK
720
KGKSKAAAER
730
MILEEFGRCL
740
MSVINSAGKA
KSDPCAMNC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0090571 |
RNA polymerase II transcription repressor complex |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0003680 |
minor groove of adenine-thymine-rich DNA binding |
| Molecular Function |
GO:0001067 |
transcription regulatory region nucleic acid binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0034728 |
nucleosome organization |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
Reference
PMID: N/A