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Overview

Uniprot IDQ6N021
Protein NameMethylcytosine dioxygenase TET2
Gene NameTET2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
87 QESRGYSKCLQNGGI
900 ASVLQGYKNRNQDMS

Function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT

Protein Sequence

10 MEQDRTNHVE 20 GNRLSPFLIP 30 SPPICQTEPL 40 ATKLQNGSPL 50 PERAHPEVNG 60 DTKWHSFKSY 70 YGIPCMKGSQ 80 NSRVSPDFTQ 90 ESRGYSKCLQ 100 NGGIKRTVSE 110 PSLSGLLQIK 120 KLKQDQKANG 130 ERRNFGVSQE 140 RNPGESSQPN 150 VSDLSDKKES 160 VSSVAQENAV 170 KDFTSFSTHN 180 CSGPENPELQ 190 ILNEQEGKSA 200 NYHDKNIVLL 210 KNKAVLMPNG 220 ATVSASSVEH 230 THGELLEKTL 240 SQYYPDCVSI 250 AVQKTTSHIN 260 AINSQATNEL 270 SCEITHPSHT 280 SGQINSAQTS 290 NSELPPKPAA 300 VVSEACDADD 310 ADNASKLAAM 320 LNTCSFQKPE 330 QLQQQKSVFE 340 ICPSPAENNI 350 QGTTKLASGE 360 EFCSGSSSNL 370 QAPGGSSERY 380 LKQNEMNGAY 390 FKQSSVFTKD 400 SFSATTTPPP 410 PSQLLLSPPP 420 PLPQVPQLPS 430 EGKSTLNGGV 440 LEEHHHYPNQ 450 SNTTLLREVK 460 IEGKPEAPPS 470 QSPNPSTHVC 480 SPSPMLSERP 490 QNNCVNRNDI 500 QTAGTMTVPL 510 CSEKTRPMSE 520 HLKHNPPIFG 530 SSGELQDNCQ 540 QLMRNKEQEI 550 LKGRDKEQTR 560 DLVPPTQHYL 570 KPGWIELKAP 580 RFHQAESHLK 590 RNEASLPSIL 600 QYQPNLSNQM 610 TSKQYTGNSN 620 MPGGLPRQAY 630 TQKTTQLEHK 640 SQMYQVEMNQ 650 GQSQGTVDQH 660 LQFQKPSHQV 670 HFSKTDHLPK 680 AHVQSLCGTR 690 FHFQQRADSQ 700 TEKLMSPVLK 710 QHLNQQASET 720 EPFSNSHLLQ 730 HKPHKQAAQT 740 QPSQSSHLPQ 750 NQQQQQKLQI 760 KNKEEILQTF 770 PHPQSNNDQQ 780 REGSFFGQTK 790 VEECFHGENQ 800 YSKSSEFETH 810 NVQMGLEEVQ 820 NINRRNSPYS 830 QTMKSSACKI 840 QVSCSNNTHL 850 VSENKEQTTH 860 PELFAGNKTQ 870 NLHHMQYFPN 880 NVIPKQDLLH 890 RCFQEQEQKS 900 QQASVLQGYK 910 NRNQDMSGQQ 920 AAQLAQQRYL 930 IHNHANVFPV 940 PDQGGSHTQT 950 PPQKDTQKHA 960 ALRWHLLQKQ 970 EQQQTQQPQT 980 ESCHSQMHRP 990 IKVEPGCKPH 1000 ACMHTAPPEN 1010 KTWKKVTKQE 1020 NPPASCDNVQ 1030 QKSIIETMEQ 1040 HLKQFHAKSL 1050 FDHKALTLKS 1060 QKQVKVEMSG 1070 PVTVLTRQTT 1080 AAELDSHTPA 1090 LEQQTTSSEK 1100 TPTKRTAASV 1110 LNNFIESPSK 1120 LLDTPIKNLL 1130 DTPVKTQYDF 1140 PSCRCVEQII 1150 EKDEGPFYTH 1160 LGAGPNVAAI 1170 REIMEERFGQ 1180 KGKAIRIERV 1190 IYTGKEGKSS 1200 QGCPIAKWVV 1210 RRSSSEEKLL 1220 CLVRERAGHT 1230 CEAAVIVILI 1240 LVWEGIPLSL 1250 ADKLYSELTE 1260 TLRKYGTLTN 1270 RRCALNEERT 1280 CACQGLDPET 1290 CGASFSFGCS 1300 WSMYYNGCKF 1310 ARSKIPRKFK 1320 LLGDDPKEEE 1330 KLESHLQNLS 1340 TLMAPTYKKL 1350 APDAYNNQIE 1360 YEHRAPECRL 1370 GLKEGRPFSG 1380 VTACLDFCAH 1390 AHRDLHNMQN 1400 GSTLVCTLTR 1410 EDNREFGGKP 1420 EDEQLHVLPL 1430 YKVSDVDEFG 1440 SVEAQEEKKR 1450 SGAIQVLSSF 1460 RRKVRMLAEP 1470 VKTCRQRKLE 1480 AKKAAAEKLS 1490 SLENSSNKNE 1500 KEKSAPSRTK 1510 QTENASQAKQ 1520 LAELLRLSGP 1530 VMQQSQQPQP 1540 LQKQPPQPQQ 1550 QQRPQQQQPH 1560 HPQTESVNSY 1570 SASGSTNPYM 1580 RRPNPVSPYP 1590 NSSHTSDIYG 1600 STSPMNFYST 1610 SSQAAGSYLN 1620 SSNPMNPYPG 1630 LLNQNTQYPS 1640 YQCNGNLSVD 1650 NCSPYLGSYS 1660 PQSQPMDLYR 1670 YPSQDPLSKL 1680 SLPPIHTLYQ 1690 PRFGNSQSFT 1700 SKYLGYGNQN 1710 MQGDGFSSCT 1720 IRPNVHHVGK 1730 LPPYPTHEMD 1740 GHFMGATSRL 1750 PPNLSNPNMD 1760 YKNGEHHSPS 1770 HIIHNYSAAP 1780 GMFNSSLHAL 1790 HLQNKENDML 1800 SHTANGLSKM 1810 LPALNHDRTA 1820 CVQGGLHKLS 1830 DANGQEKQPL 1840 ALVQGVASGA 1850 EDNDEVWSDS 1860 EQSFLDPDIG 1870 GVAVAPTHGS 1880 ILIECAKREL 1890 HATTPLKNPN 1900 RNHPTRISLV 1910 FYQHKSMNEP 1920 KHGLALWEAK 1930 MAEKAREKEE 1940 ECEKYGPDYV 1950 PQKSHGKKVK 1960 REPAEPHETS 1970 EPTYLRFIKS 1980 LAERTMSVTT 1990 DSTVTTSPYA 2000 FTRVTGPYNR YI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0070579 DNA 5-methylcytosine dioxygenase activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008198 ferrous iron binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0002521 leukocyte differentiation
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006493 protein O-linked glycosylation

Reference

PMID: N/A