Search Results
Overview
| Uniprot ID | Q6NSI4 |
|---|---|
| Protein Name | RPA-related protein RADX |
| Gene Name | RADX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 671 | INANLQGKARKTISD |
Function
Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897)
Protein Sequence
10
MSGESGQPEA
20
GPSHAGLDWP
30
NPERNRAGVP
40
GGVIRRAGSQ
50
GPRSWIQKVL
60
EQIMDSPRQC
70
VTPSEVVPVT
80
VLAVQRYLLE
90
DEPRDTVPKP
100
PLYCYDVTIS
110
DGVYQEKCYL
120
DPSLNSLVYQ
130
NILKVGIQMR
140
ISRVSCLYNE
150
KRIGQGILCI
160
DNVHCGETSD
170
SISLETPFRN
180
RAHQEKPERP
190
LRGGKSHYLA
200
LWNNEDPYGD
210
IWLTDKQPEE
220
HNFSDTKIIS
230
LSHLEMTWTN
240
RRNFPALLVR
250
ILHKSKLRYY
260
GKPDKKMIEP
270
YQTFLEVADS
280
SGTVSVIMWN
290
ALCPEWYKSL
300
RVGLVLLLQD
310
YSVKKSYPFR
320
IQPVPVDPQI
330
KLISTMEICL
340
NLRDPPTNII
350
IIPEKQVKPE
360
WRLPKLNHRF
370
TTRSELDDMP
380
ENCICDVIGL
390
LVFVGRVQRS
400
KKKENREDFW
410
SYRWIHIADG
420
TSEQPFIVEL
430
FSTSQPEIFE
440
NIYPMAYFVC
450
TQLKVVRNDN
460
QVPKLLYLTT
470
TNESGVFITG
480
HRGQPYTYDA
490
KVKNFIQWIR
500
TKSDSGEQKN
510
MVIGGYYPYP
520
PVPETFSKYS
530
SSIKVESLLT
540
AISEVRKEIE
550
DLQYREQKRI
560
AIQGIITAIK
570
YIPHSSATES
580
ASASETLRNA
590
NRPSTSQAAR
600
VEIQERNGKR
610
HQDDEPVNSQ
620
YFQTTSTNLS
630
LSNKIRILQG
640
PHANPVAVPQ
650
PGASVQTKGI
660
KPGMPSIFNR
670
RANINANLQG
680
KARKTISDRW
690
ESQLWREKKF
700
GLIDHLHYSR
710
VYPESIPRKF
720
MFEHRKFLSD
730
QYNSQPAKYV
740
PPEGRPPKLD
750
DFKSARSLGH
760
FEVTILGLNH
770
EIAIDVAFLP
780
MYCPEDIRTS
790
QIDTLLTSMN
800
YSCAYPQDTT
810
GNDRLPGPRA
820
VAGDIIKAAT
830
ELDRVHIVGI
840
LDICNLGNNK
850
VEVYLHKIYS
PENTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005657 | replication fork |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:2000042 | negative regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0006282 | regulation of DNA repair |
Reference
PMID: N/A