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Overview

Uniprot ID	Q6NUJ5
Protein Name	PWWP domain-containing protein 2B
Gene Name	PWWP2B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
263	SYSTPQGKGEVVKIP
268	QGKGEVVKIPSRVHG

Function

Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity)

Protein Sequence

10 MEPRAGCRLP 20 VRVEQVVNGA 30 LVVTVSCGER 40 SFAGILLDCT 50 KKSGLFGLPP 60 LAPLPQVDES 70 PVNDSHGRAP 80 EEGDAEVMQL 90 GSSSPPPARG 100 VQPPETTRPE 110 PPPPLVPPLP 120 AGSLPPYPPY 130 FEGAPFPHPL 140 WLRDTYKLWV 150 PQPPPRTIKR 160 TRRRLSRNRD 170 PGRLILSTIR 180 LRPRQVLCEK 190 CKSTLSPPEA 200 SPGPPAAPRA 210 RRRLGSGPDR 220 ELRKPEEPEN 230 GEPTAAATAR 240 RSKRERREED 250 RAPAEQVPRS 260 PVIKISYSTP 270 QGKGEVVKIP 280 SRVHGSLEPF 290 RPQQAPQDDG 300 SQDPEVLDRE 310 SRDRPSCAPS 320 ASIPKLKLTR 330 PVPAGADLPP 340 PKIRLKPHRL 350 GDSEHEPVYR 360 AELVGELNGY 370 LRDSSPAPCA 380 DGPAGGLADL 390 SSGSSGEDDD 400 FKSCPQGPQG 410 REGLAFLVSC 420 PEGRADCASE 430 SACSSDSLDE 440 ARSSGSEGTP 450 ADTGDLSPGH 460 GASAPSVSRE 470 ARQTVPPLTV 480 RLHTQSVSEC 490 ITEDGRTVAV 500 GDIVWGKIHG 510 FPWWPARVLD 520 ISLGQKEDGE 530 PSWREAKVSW 540 FGSPTTSFLS 550 ISKLSPFSEF 560 FKLRFNRKKK 570 GMYRKAITEA 580 ANAARHVAPE 590 IRELLTQFET

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0120325	NuRD complex binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II
Biological Process	GO:0120161	regulation of cold-induced thermogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.