Search Results

Overview

Uniprot IDQ6NUK1
Protein NameMitochondrial adenyl nucleotide antiporter SLC25A24
Gene NameSLC25A24
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
228 MMQVHGSKSDKMNIF
320 KTRLAVGKTGQYSGI
336 DCAKKILKHEGLGAF
437 LFRRIISKEGIPGLY
74 GDVNKDGKLDFEEFM

Function

Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093)

Protein Sequence

10 MLRWLRDFVL 20 PTAACQDAEQ 30 PTRYETLFQA 40 LDRNGDGVVD 50 IGELQEGLRN 60 LGIPLGQDAE 70 EKIFTTGDVN 80 KDGKLDFEEF 90 MKYLKDHEKK 100 MKLAFKSLDK 110 NNDGKIEASE 120 IVQSLQTLGL 130 TISEQQAELI 140 LQSIDVDGTM 150 TVDWNEWRDY 160 FLFNPVTDIE 170 EIIRFWKHST 180 GIDIGDSLTI 190 PDEFTEDEKK 200 SGQWWRQLLA 210 GGIAGAVSRT 220 STAPLDRLKI 230 MMQVHGSKSD 240 KMNIFGGFRQ 250 MVKEGGIRSL 260 WRGNGTNVIK 270 IAPETAVKFW 280 AYEQYKKLLT 290 EEGQKIGTFE 300 RFISGSMAGA 310 TAQTFIYPME 320 VMKTRLAVGK 330 TGQYSGIYDC 340 AKKILKHEGL 350 GAFYKGYVPN 360 LLGIIPYAGI 370 DLAVYELLKS 380 YWLDNFAKDS 390 VNPGVMVLLG 400 CGALSSTCGQ 410 LASYPLALVR 420 TRMQAQAMLE 430 GSPQLNMVGL 440 FRRIISKEGI 450 PGLYRGITPN 460 FMKVLPAVGI 470 SYVVYENMKQ TLGVTQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0000295 adenine nucleotide transmembrane transporter activity
Molecular Function GO:0140988 ADP:phosphate antiporter activity
Molecular Function GO:0005347 ATP transmembrane transporter activity
Molecular Function GO:0140987 ATP:phosphate antiporter activity
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0051503 adenine nucleotide transport
Biological Process GO:0015866 ADP transport
Biological Process GO:0015867 ATP transport
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:1990544 mitochondrial ATP transmembrane transport
Biological Process GO:0006839 mitochondrial transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.