Search Results
Overview
| Uniprot ID | Q6NUM9 |
|---|---|
| Protein Name | All-trans-retinol 13,14-reductase |
| Gene Name | RETSAT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 589 | LCSSAILKRNLYSDL |
Function
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation
Protein Sequence
10
MWLPLVLLLA
20
VLLLAVLCKV
30
YLGLFSGSSP
40
NPFSEDVKRP
50
PAPLVTDKEA
60
RKKVLKQAFS
70
ANQVPEKLDV
80
VVIGSGFGGL
90
AAAAILAKAG
100
KRVLVLEQHT
110
KAGGCCHTFG
120
KNGLEFDTGI
130
HYIGRMEEGS
140
IGRFILDQIT
150
EGQLDWAPLS
160
SPFDIMVLEG
170
PNGRKEYPMY
180
SGEKAYIQGL
190
KEKFPQEEAI
200
IDKYIKLVKV
210
VSSGAPHAIL
220
LKFLPLPVVQ
230
LLDRCGLLTR
240
FSPFLQASTQ
250
SLAEVLQQLG
260
ASSELQAVLS
270
YIFPTYGVTP
280
NHSAFSMHAL
290
LVNHYMKGGF
300
YPRGGSSEIA
310
FHTIPVIQRA
320
GGAVLTKATV
330
QSVLLDSAGK
340
ACGVSVKKGH
350
ELVNIYCPIV
360
VSNAGLFNTY
370
EHLLPGNARC
380
LPGVKQQLGT
390
VRPGLGMTSV
400
FICLRGTKED
410
LHLPSTNYYV
420
YYDTDMDQAM
430
ERYVSMPREE
440
AAEHIPLLFF
450
AFPSAKDPTW
460
EDRFPGRSTM
470
IMLIPTAYEW
480
FEEWQAELKG
490
KRGSDYETFK
500
NSFVEASMSV
510
VLKLFPQLEG
520
KVESVTAGSP
530
LTNQFYLAAP
540
RGACYGADHD
550
LGRLHPCVMA
560
SLRAQSPIPN
570
LYLTGQDIFT
580
CGLVGALQGA
590
LLCSSAILKR
600
NLYSDLKNLD
610
SRIRAQKKKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005640 | nuclear outer membrane |
| Molecular Function | GO:0051786 | all-trans-retinol 13,14-reductase activity |
| Biological Process | GO:0042572 | retinol metabolic process |
Reference
PMID: N/A