Search Results

Overview

Uniprot ID	Q6NUN0
Protein Name	Acyl-coenzyme A synthetase ACSM5, mitochondrial
Gene Name	ACSM5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	ELGKQSRKAANVLGG
566	LPKTVSGKIQRSKLR

Function

Acyl-CoA synthetase that catalyzes the ATP-dependent activation of fatty acids to their corresponding acyl-CoA thioesters, the first committed step in fatty acid metabolism (By similarity). Negatively regulates lipid accumulation via inhibition of FABP4-PPARgamma signaling (PubMed:37957699)

Protein Sequence

10 MRPWLRHLVL 20 QALRNSRAFC 30 GSHGKPAPLP 40 VPQKIVATWE 50 AISLGRQLVP 60 EYFNFAHDVL 70 DVWSRLEEAG 80 HRPPNPAFWW 90 VNGTGAEIKW 100 SFEELGKQSR 110 KAANVLGGAC 120 GLQPGDRMML 130 VLPRLPEWWL 140 VSVACMRTGT 150 VMIPGVTQLT 160 EKDLKYRLQA 170 SRAKSIITSD 180 SLAPRVDAIS 190 AECPSLQTKL 200 LVSDSSRPGW 210 LNFRELLREA 220 STEHNCMRTK 230 SRDPLAIYFT 240 SGTTGAPKMV 250 EHSQSSYGLG 260 FVASGRRWVA 270 LTESDIFWNT 280 TDTGWVKAAW 290 TLFSAWPNGS 300 CIFVHELPRV 310 DAKVILNTLS 320 KFPITTLCCV 330 PTIFRLLVQE 340 DLTRYQFQSL 350 RHCLTGGEAL 360 NPDVREKWKH 370 QTGVELYEGY 380 GQSETVVICA 390 NPKGMKIKSG 400 SMGKASPPYD 410 VQIVDDEGNV 420 LPPGEEGNVA 430 VRIRPTRPFC 440 FFNCYLDNPE 450 KTAASEQGDF 460 YITGDRARMD 470 KDGYFWFMGR 480 NDDVINSSSY 490 RIGPVEVESA 500 LAEHPAVLES 510 AVVSSPDPIR 520 GEVVKAFIVL 530 TPAYSSHDPE 540 ALTRELQEHV 550 KRVTAPYKYP 560 RKVAFVSELP 570 KTVSGKIQRS KLRSQEWGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0015645	fatty acid ligase activity
Molecular Function	GO:0004321	fatty-acyl-CoA synthase activity
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006637	acyl-CoA metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.