Search Results
Overview
| Uniprot ID | Q6NUN9 |
|---|---|
| Protein Name | Zinc finger protein 746 |
| Gene Name | ZNF746 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 442 | GHKPGLKKHPAAPPG |
Function
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death
Protein Sequence
10
MAEAVAAPIS
20
PWTMAATIQA
30
MERKIESQAA
40
RLLSLEGRTG
50
MAEKKLADCE
60
KTAVEFGNQL
70
EGKWAVLGTL
80
LQEYGLLQRR
90
LENVENLLRN
100
RNFWILRLPP
110
GSKGESPKEW
120
GKLEDWQKEL
130
YKHVMRGNYE
140
TLVSLDYAIS
150
KPEVLSQIEQ
160
GKEPCNWRRP
170
GPKIPDVPVD
180
PSPGSGPPVP
190
APDLLMQIKQ
200
EGELQLQEQQ
210
ALGVEAWAAG
220
QPDIGEEPWG
230
LSQLDSGAGD
240
ISTDATSGVH
250
SNFSTTIPPT
260
SWQTDLPPHH
270
PSSACSDGTL
280
KLNTAASTED
290
VKIVIKTEVQ
300
EEEVVATPVH
310
PTDLEAHGTL
320
FGPGQATRFF
330
PSPAQEGAWE
340
SQGSSFPSQD
350
PVLGLREPAR
360
PERDMGELSP
370
AVAQEETPPG
380
DWLFGGVRWG
390
WNFRCKPPVG
400
LNPRTGPEGL
410
PYSSPDNGEA
420
ILDPSQAPRP
430
FNEPCKYPGR
440
TKGFGHKPGL
450
KKHPAAPPGG
460
RPFTCATCGK
470
SFQLQVSLSA
480
HQRSCGAPDG
490
SGPGTGGGGS
500
GSGGGGGGSG
510
GGSARDGSAL
520
RCGECGRCFT
530
RPAHLIRHRM
540
LHTGERPFPC
550
TECEKRFTER
560
SKLIDHYRTH
570
TGVRPFTCTV
580
CGKSFIRKDH
590
LRKHQRNHAA
600
GAKTPARGQP
610
LPTPPAPPDP
620
FKSPASKGPL
630
ASTDLVTDWT
640
CGLSVLGPTD
GGDM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051291 | protein heterooligomerization |
| Biological Process | GO:0051260 | protein homooligomerization |
Reference
PMID: N/A