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Overview

Uniprot ID	Q6NUT2
Protein Name	Probable C-mannosyltransferase DPY19L2
Gene Name	DPY19L2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
95	SLAQLREKVQELQAR

Function

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins

Protein Sequence

10 MRKQGVSSKR 20 LQSSGRSQSK 30 GRRGASLARE 40 PEVEEEMEKS 50 ALGGGKLPRG 60 SWRSSPGRIQ 70 SLKERKGLEL 80 EVVAKTFLLG 90 PFQFVRNSLA 100 QLREKVQELQ 110 ARRFSSRTTL 120 GIAVFVAILH 130 WLHLVTLFEN 140 DRHFSHLSSL 150 EREMTFRTEM 160 GLYYSYFKTI 170 IEAPSFLEGL 180 WMIMNDRLTE 190 YPLIINAIKR 200 FHLYPEVIIA 210 SWYCTFMGIM 220 NLFGLETKTC 230 WNVTRIEPLN 240 EVQSCEGLGD 250 PACFYVGVIF 260 ILNGLMMGLF 270 FMYGAYLSGT 280 QLGGLITVLC 290 FFFNHGEATR 300 VMWTPPLRES 310 FSYPFLVLQM 320 CILTLILRTS 330 SNDRRPFIAL 340 CLSNVAFMLP 350 WQFAQFILFT 360 QIASLFPMYV 370 VGYIEPSKFQ 380 KIIYMNMISV 390 TLSFILMFGN 400 SMYLSSYYSS 410 SLLMTWAIIL 420 KRNEIQKLGV 430 SKLNFWLIQG 440 SAWWCGTIIL 450 KFLTSKILGV 460 SDHIRLSDLI 470 AARILRYTDF 480 DTLIYTCAPE 490 FDFMEKATPL 500 RYTKTLLLPV 510 VMVITCFIFK 520 KTVRDISYVL 530 ATNIYLRKQL 540 LEHSELAFHT 550 LQLLVFTALA 560 ILIMRLKMFL 570 TPHMCVMASL 580 ICSRQLFGWL 590 FRRVRFEKVI 600 FGILTVMSIQ 610 GYANLRNQWS 620 IIGEFNNLPQ 630 EELLQWIKYS 640 TTSDAVFAGA 650 MPTMASIKLS 660 TLHPIVNHPH 670 YEDADLRART 680 KIVYSTYSRK 690 SAKEVRDKLL 700 ELHVNYYVLE 710 EAWCVVRTKP 720 GCSMLEIWDV 730 EDPSNAANPP 740 LCSVLLEDAR 750 PYFTTVFQNS VYRVLKVN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005637	nuclear inner membrane
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000030	mannosyltransferase activity
Biological Process	GO:0007286	spermatid development

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.